Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory Activities of Torilis japonica Fruit

사상자의 항염증작용

  • Kim, Sang-Mee (College of Pharmacy, Sookmyung Women's University) ;
  • Kim, Tae-Hee (College of Pharmacy, Sookmyung Women's University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • 김상미 (숙명여자대학교 약학대학) ;
  • 김태희 (숙명여자대학교 약학대학) ;
  • 이은방 (서울대학교 천연물과학연구소)
  • Published : 1998.12.30
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Abstract

The methanol extract of Torilis Fructus showed potent anti-edematous effect in carrageenan-induced paw edema in rats. Systematic fractionation of the extract with hexane, chloroform, ethyl acetate and butanol resulted in potent anti-edematous action only in hexane fraction at an oral dose of 237 mg/kg which is corresponding to 4.8 g of raw Fructus. This hexane fraction showed inhibitory effects at 77 mg/kg p.o on vascular permeability in mice, at 8mg/pouch on leucocyte emigration in rats, and at 120 mg/kg p.o. on adjuvant arthritis model in rats. These results demonstrate that hexane fraction of the extract possesses potent anti-inflammatory effect which may support its traditional uses.

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