생약학회지 (Korean Journal of Pharmacognosy)

  • 제29권3호
  • /
  • Pages.198-203
  • /
  • 1998
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

한국산 생약으로부터 항암물질의 개발(제 8보) - 포공령 추출물이 인체 피부흑색종세포에 미치는 세포독성작용 -

Development of Anticancer Agents from Korean Medicinal Plants (Part 8). - Cytotoxic Activity of Taraxaci Herba Extract against Human Skin Melanoma Cells -

  • 오인교 (원광보건대학 환경공업과) ;
  • 유은아 (성신여자대학교 자연과학대학 화학과) ;
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 강길웅 (원광대학교 자연과학대학 화학과) ;
  • 백승화 (원광대학교 자연과학대학 화학과)
  • Oh, In-Kio (Department of Environmental Industry, Wonkwang Health College) ;
  • Yoo, Eun-Ah (Department of Chemistry, College of Natural Sciences, Sungshin Women's University) ;
  • Han, Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Kang, Kil-Ung (Department of Chemistry, College of Natural Sciences, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Chemistry, College of Natural Sciences, Wonkwang University)
  • 발행 : 1998.09.30
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초록

In the present study, we have evaluated cytotoxic effects of Taraxaci herba extract on human skin melanoma cells. The light microscopic study showed morphological changes of the treated cells. Disruptions in cell organelles were determined by calorimetric methods: MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide), NR (Neutral red) and SRB (Sulforhodamine B protein) assay. These results suggest that Taraxaci herba retains a potential antitumor activity.

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