조구등 성분의 항경련효과 II. - 메탄올 추출물 및 에틸 아세테이트 분획의 뇌 신경전달 관련물질에 미치는 효과 -

Anticonvulsant Effect of Uncariae Ramulus et Uncus II. - Effects of Methanol Extract and Ethyl Acetate Fraction on Neurotransmitters related Components in Brain -

The fractions of Uncariae Ramulus et Uncus seemed to be closely related with the levels of amino acids and other components which concerns with formation and metabolism of neurotransmitters in brain. The pretreatments of methanolic extract and its fractions prohibited the pentylenetetrazole (PTZ) induced convulsion. In such cases, lowered levels of ${\gamma}-aminobutyric$ acid and glutathione in brain were significantly recovered. And also the increased levels or activities of lipid peroxide, ${\gamma}-aminobutyric$ acid aminotransferase, xanthine oxidase, aldehyde oxidase, superoxide dismutase, catalase and glutathione peroxidase by PTZ-convulsion were lowered to normal state.