The Screening of Fibrinolytic Activities of Extracts from Mushrooms in Mt. Chiak

치악산 버섯추출물로부터 Fibrin 분해활성의 검색

  • Kim, Jun-Ho (Department of Chemistry, Sang Ji University) ;
  • Lee, Ho-Yong (Department of Biology, Sang Ji University) ;
  • Yoo, Kwan-Hee (Department of Biology, Sang Ji University) ;
  • Kim, Yang-Sun (College of General Education, Semyoung University) ;
  • Seok, Soon-Ja (National Agricultural Science and Technology Institute, RDA.) ;
  • Kim, Yang-Sup (National Agricultural Science and Technology Institute, RDA.)
  • 김준호 (상지대학교 이공과대학 화학과) ;
  • 이호용 (상지대학교 이공과대학 생물과) ;
  • 유관희 (상지대학교 이공과대학 생물과) ;
  • 김양선 (세명대학교 교양학부) ;
  • 석순자 (농촌진흥청 농업과학기술원) ;
  • 김양섭 (농촌진흥청 농업과학기술원)
  • Published : 1998.12.30

Abstract

Extracts from 65 species of mushrooms in mount Chiak were screened for their fibrinolytic activities. Extracts from Armillariella mellea, Calocybe sp., Lepista nuda and Trichaptum abietinum showed to have almost twice of activity of plasmin 1.5 U/ml, 193%, 213%, 198%, and 193% respectively. Collybia maculata showed 98% of activity, and Coprinus comatus and Lepiota sp. 56% and 58% activities, respectively. Other two, Agrocybe sp. and Stropharia rugosoannulata were less than 10% of activities.

치악산에 자생하는 야생버섯 65종에서 fibrin 분해활성을 검색하였으며, 그 결과 9종의 버섯이 활성을 나타냈다. Agrocybe sp.와 Stropharia rugosoannulata는 작은 활성률을 보였으며, Lepiota sp.와 Coprinus comatus는 plasmin 1.5 unit의 $56%{\sim}58%$의 fibrin 분해활성을 보인 반면 Collybia maculata는 plasmin 1.5 unit와 거의 같은 활성을 보였고 Armillariella mellea와 Calocybe sp.와 Lepista nuda와 Trichaptum abietinum은 plasmin 1.5 unit의 약 2배의 fibrin 분해활성을 나타냈다.

Keywords

References

  1. 병리학 최진
  2. Kor. J. Mycol. v.20 Medical Fungi in Korea Ahn, D.K.
  3. Thrombosis and Haemostasis Bachmann, F.
  4. Biochim Biophys Acta (NETHERLANDS) v.954 no.2 Autolysis and inhibition of proteinase K, a subtilisin-related serine proteinase isolated from the fungus Tritirachium album Limber Bajorth, J.;Saenger, W.;Pal, G.P.
  5. Toxicon v.18 no.3 Fibrinolytic enzyme(s) in western diamondback rattlesnake (Crotalus atrox) venom Bajwa, S.S.;Markland, F.S.;Russell, F.E.
  6. Toxion v.19 no.1 Fibrinolytic and fibrinogen clotting enzymes present in the venoms of western diamondback rattlesnake, Crotalus atrox, eastern diamondback rattlesnake, Crotalus adamanteus, and southern Pacific rattlesnake, Crotalus viridis helleri Bajwa, S.S.;Markland, F.S.;Russell, F.E.
  7. J. Gen. Microbiol. v.139 Purification and characterization of a serine proteinase from senescent sporophores of the commercial mushroom Agaricus bisporus Burton, K.S.;Wood, D.A.;Thurston, C.F.;Barker, P.J.
  8. Proceedings of the 2nd Symposium on the Biochemical Methodology for the R&d of the Bioactive Substances Chung, K.H.
  9. Mikol. Fitopatol. v.9 (Russ) Proteolytic enzyme isolated from a fungus, Flammulina velutipes (Fr) Sing Gavrilova, V.P.;Falina, N.N.
  10. Thromb. Haemostas v.32 Doseresponse curves in the fibrin plate assay. Fibrinolytic activity of protease Haverkate, F.;Traas, D.W.
  11. Kor. J. Mycol. v.11 Studies on constituents of the Higher Fungi of Korea (XXXVII) Kim, B.K.;Kim, J.S.;Choi, E.C.;Kim, H.R.;Lee, K.L.;Lee, C.O.;Chung, K.S.;Shim, M.J.
  12. Kor. J. Microbiol. Biotechnol. v.23 Screening and Identification of the Fibrinolytic Bacterial Strain from ChungKooK-jang Kim, Y.T.;Kim, W.K.;Oh, H.S.
  13. J. Biol. Chem. v.193 Protein Measurement with the folin Phenol reagent Lowry, O.H.;Rosenbrough, N.J.;Randall, A.J.
  14. Biosci. Biotech. Biochem v.57 no.10 Characterijation of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus Mihara, H.;Nakajima, N.;Sumi, H.
  15. Japanese Journal of Physiology v.41 A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus Mihara, H.;Sumi, H.;Yoneta, T.;Mizumoto, H.;Ikeda, R.;Seiki, M.;Maruyama, M.
  16. Biochim. Biophy. Acta v.420 no.2 Fibrinolytic enzymes of Trimeresurus mucrosquamatus venom Ouyang, C.;Teng, C.M.
  17. Kor. J. Mycol. v.23 no.1 Study on the Screening and Development of Antibiotics in the Muthrooms. - The Screening of Bacterial Antibiotics in Basidiomycetes (I) Park, S.S.;Lee, K.D.;Min, T.J.