The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
권호 표지

Antioxidant Activities of Extracts from Fruiting Bodies of Mushrooms

버섯추출물의 항산화활성에 관한 연구

  • Published : 1998.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Antioxidant activities of 80% ethanol extracts of 63 species of mushroom fruiting bodies were investigated. The ethanol extracts from Daedalea dickinsii, Armillariella mellea, and Fomitella fraxinea showed markedly inhibition on lipid peroxidation in rat liver microsome. The extracts from Daedaleopsis tricolor, Trametes suaveolens, Armillariella mellea, Trichaptium abietinum, Daedalea dickinsii, Fomitella fraxinea, Tylophilus neofelleus, Boletellus obscurecoccineus, and Xerocomus subtomentosus significantly inhibited the hepatic aldehyde oxidase activity, and the extracts from Daedaleopsis tricolor, Armillariella mellea, Daedalea dickinsii, and Fomitella fraxinea slightly stimulated the hepatic SOD activity. These results suggest that Daedalea dickinsii, Armillariella mellea, and Fomitella fraxinea contain the bioactive substances for natural antioxidant and may be useful for development of antioxidant from mushrooms.

버섯의 항산화 활성을 검색하기 위하여 63종의 버섯자실체를 80% 에탄올로 추출한 후 각각의 버섯추출물이 지질과산화반응, AO 및 SOD의 활성도에 미치는 효과를 관찰하였다. 테미로버섯(D. dickinsii), 뽕나무버섯(A. mellea) 및 아카시재목버섯(F. fraxineu)의 추출물이 간조직 microsome의 지질과산화반응을 억제시켰으며, A. mellea, D. dickinsii, F. fraxinea, 삼색도장버섯(D. tricolor), 송편버섯(T. suaveolens), 옷솔버섯(T. abietinum), 제주쓴맛그물버섯(T. neofelleus), 노란그물버섯(B. obscurecoccineus) 및 산그물버섯(X. subtomentosus) 등의 추출물은 간 세포질 내의 초산화 이온의 생성효소인 AO 활성을 크게 억제시켰다. 한편, D. tricolor, A. mellea, D. dickinsii, 및 F. fraxinea 등의 추출물은 간 세포질의 SOD의 활성을 증가시켰다. 이상의 결과로부터 특히 A. mellea, D. dickinsii 및 F. fraxinea로부터 항산화활성 성분의 분리정제 및 생리활성물질의 개발에 대한 가능성이 제시되었다.

Keywords

References

  1. 한국생화학회지 v.14 한국산 담자균류의 항암성분에 관한 연구, 만년버섯의 균사배양 및 항암성분 강창율;심미자;최응칠;이영남;김병각
  2. 대한화학회지 v.40 Umbilicaria vellea 중 페놀성화합물의 구조 및 항균활성 민태진;배강규
  3. キノコの化學.生化學 水野卓;川合正允
  4. キノコの化學.生化學 水野卓;川合正允
  5. Science v.204 Identification of environmental chemicals causing mutation and cancer Ames, B.N.
  6. Proc. Natl. Acad. Sci. U.S.A. v.78 Uric acid provides an antioxidant defense in humans against oxidant and radical-caused aging and cancer Ames, B.N.;Cahcart, R.;Schwiers, E.;Hochstein, P.
  7. Nature v.175 Campestrin, the antibiotic of Psalliota campetris Bose, S.R.
  8. Edible mushrooms and their cultivation Chang, T.;Miles, P.G.
  9. Cancer Res. v.30 Fractionation and purification of the polysaccharides with marked antitumor activity, especially Lentinan from Lentinus edodes (Berk) Sing (an edible mushroom) Chihara, G.;Hamuro, J.;Maeda, Y.Y.;Arai, Y.;Fukuoka, F.
  10. Yakugaku Zasshi v.96 Structure studies on the antitumor active polysaccharides from Coriolus versicolor (Basidiomycetes). I. Fractionation with barium hydroxide Hirase, S.;Nakai, S.;Akstsu, T.
  11. Mol. Biotecher. v.4 no.1 Mimicking of superoxide dismutase activity by protein-bound polysaccharide of Coriolus versicolor QUEL, and oxidative stress relief for cancer patients Kariya, K.;Nakamura, K.;Nomoto, K.;Matama, S.;Saigenji, K.
  12. Heterocycle v.36 Structure of novel antioxidative lignin triglucose isolated from seasame seed Katsuzaki, H.;Kawakishi, S.;Osawa, T.
  13. Pro. Natl. Acad. Sci. USA. v.35 Antibiotic substances from basidiomycetes IV. Marasmius conigenus Kavanagh, F.;Hervey, A.;Robbins, W.J.
  14. Planta Med. v.62 Inhibitory effects of gagaminine, a steroidal alkaloid from Cynanchum wilfordi, on lipid peroxidation and aldehyde oxidase activity Lee, D.U.;Shin, U.S.;Hur, K.
  15. Chem. Pharm. Bull. Tokyo. v.44 no.5 Characterization of carbohydrate-peptide linkage of acidic heteroglycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus Lee, J.H.;Cho, S.M.;Song, K.S.;Hong. N.D.;Yoo, I.D.
  16. J. Biol. Chem. v.193 Protein measurement with the Folin-phenol reagent Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J.
  17. Science v.235 Oxygen radicals linked to many diseases Marks, J.L.
  18. Yakugaku Zasshi v.117 no.9 Studies on antioxidants of Hypsizigus marmoreus. I. Effects of Hypsizigus marmoreus for antioxidants activities of mice plasma Matsuzawa, T.;Sano, M.;Tomita, I.;Saitoh, H.;Ikekawa, T.
  19. J. Biol. Chem. v.244 Superoxide dismutase McCord, J.M.;Fridovich, I.
  20. Phytochemistry v.33 Antioxidant activity of tannins and flavonoids in Eucalyptus rostrata Okamura, H.;Mimura, A.;Yakou, Y.;Niwano, M.;Takahara, Y.
  21. Anal. Biochem. v.95 Assay for lipid peroxides animal tissues by thiobarbituric acid reaction Okawa, H.;Ohishi, N.;Yagi, K.
  22. J. Roy. Soc. Health. v.111 Oxygen free radicals and human disease Okezie, I.A.;Kaur, H.;Halliwell, B.
  23. Korean J. Pharmacol. v.21 Effects of nitrofurantoin on lipid peroxidation and reactive oxygen radical generation in porcine lung microsome Paick, J.S.;Kim, S.W.;Kim, H.W.;Chung, M.H.;Kim, M.S.
  24. J. Biol. Chem. v.237 Hepatic aldehyde oxidase. I. Purification and properties Rajagopalan, K.V.;Fridovich, I.;Handler, P.
  25. Toxicol. Appl. Pharmacol. v.60 In vitro stimulation by paraguat of reactive oxygen-mediated lipid peroxidation in rat lung microsome Trush, M.A.;Mimnaugh, E.G.;Ginburg, E.;Gram, T.E.
  26. J. Agic. Food. Chem. v.42 Antioxidative activity of the Anthocyanin pigments cyanidin 3-O-${\beta}$-D-Glucoside and cyanidin Tsuda, T.;Watanabe, M.;Ohshima, K.;Norinobu, S.;Choi, S.W.;Kawakishi, S.;Osawa, T.
  27. J. Agric. Food. Chem. v.43 Antioxidant activity of various tea extracts in relation to their antimutagenecity Yen, G.C.;Chen, H.Y.