The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 6
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- Pages.753-761
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Involvement of Adenosine in Cardioprotective Effect of Catecholamine Preconditioning in Ischemia-Reperfused Heart of Rat
- Kim, Young-Hoon (Department of Pharmacology & Heart Research Institute, Seoul National University College of Medicine) ;
- Kim, Chan-Hyung (Department of Pharmacology & Heart Research Institute, Seoul National University College of Medicine) ;
- Kim, Gi-Tae (Department of Pharmacology & Heart Research Institute, Seoul National University College of Medicine) ;
- Kim, In-Kyu (Department of Pediatrics, College of Medicine, Pochon CHA University) ;
- Park, Jong-Wan (Department of Pharmacology & Heart Research Institute, Seoul National University College of Medicine) ;
- Kim, Myung-Suk (Department of Pharmacology & Heart Research Institute, Seoul National University College of Medicine)
- Published : 1998.12.21
Abstract
Preconditioning of a heart with small doses of catecholamines induces a tolerance against the subsequent lethal ischemia. The present study was performed to find a specific receptor pathway involved with the catecholamine preconditioning and to test if adenosine plays a role in this cardioprotective effect. Isolated rat hearts, pretreated with small doses of