The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 4
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- Pages.493-501
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Interaction of $17{\beta}-Estradiol$ with EGF and IGF-I on Proliferation and $P_i$ Uptake in Primary Cultured Rabbit Renal Proximal Tubular Cells
- Han, Ho-Jae (Department of Veterinary Physiology, College of Veterinary Medicine, Hormone Research Center, Chonnam National University) ;
- Lee, Yeun-Hee (Department of Veterinary Physiology, College of Veterinary Medicine, Hormone Research Center, Chonnam National University)
- Published : 1998.08.21
Abstract
The most significant direct role of estrogen in vivo is its ability to elicit receptor-mediated cellular proliferation in mammalian target tissues. However, the mechanism by which exogenously added estrogen causes the neoplastic transformation of renal cortical cells is yet to be uncovered. The present study was designed to evaluate interaction of