The Korean Journal of Physiology and Pharmacology
- 제2권4호
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- Pages.427-433
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Cytoprotective Effects of Dihydrolipoic Acid and Lipoic Acid on the Oxidative Stress in Cultured Rat Cortical Neurons
- Kim, Won-Ki (Department of Pharmacology, College of Medicine,Division of Neuroscience, Medical Research Center, Ewha Womans University)
- 발행 : 1998.08.21
초록
In brain hypoxic-ischemia, an excess release of glutamate and a marked production of reactive oxygen species (ROS) occur in neuronal and non-neuronal cells. The present study investigated the effect of the biological antioxidants dihydrolipoic acid (DHLA) and lipoic acid (LA) on N-methyl-D-aspartate (NMDA)- and ROS-induced neurotoxicity in cultured rat cortical neurons. DHLA enhanced NMDA-evoked rises in intracellular calcium concentration (
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