The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 3
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- Pages.395-401
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
In Vitro Cytotoxicity of Novel Platinum(II) Coordination Complexes Containing Diaminocyclohexane and Diphenylphosphines
- Jung, Jee-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
- Kim, Young-Kyu (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
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Park, Seung-Joon
(Department of Pharmacology, School of Medicine, Kyung Hee University) ;
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Chung, Joo-Ho
(Department of Pharmacology, School of Medicine, Kyung Hee University) ;
- Chang, Sung-Goo (Department of Urology, School of Medicine, Kyung Hee University) ;
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Lee, Kyung-Tae
(Department of Biochemistry, College of Pharmacy, Kyung Hee University) ;
- Baek, Min-Son (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University) ;
- Park, Jong-Jip (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University) ;
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Rho, Young-Soo
(Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
- Published : 1998.06.21
Abstract
We have synthesized new platinum(II) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of