The Korean Journal of Physiology and Pharmacology
- 제2권3호
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- Pages.323-330
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat
- Chong, Won-Seog (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Lee, Young-Soo (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Kang, Young-Jin (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Lee, Duck-Hyung (Department of Chemistry, Sogang University) ;
- Ryu, Jae-Chun (Doping Control Center, Korea Institute of Science and Technology) ;
- Yun-Choi, Hye-Sook (Natural Product Research Institute, Seoul National University) ;
- Chang, Ki-Churl (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National University)
- 발행 : 1998.06.21
초록
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series of THI, using rats' isolated atria and aorta. In addition, a