The Korean Journal of Physiology and Pharmacology
- 제2권3호
- /
- Pages.287-295
- /
- 1998
- /
- 1226-4512(pISSN)
- /
- 2093-3827(eISSN)
Influence of the Central Benzodiazepinergic System on Peripheral Cardiovascular Regulation
- Koh, Jeong-Tae (Departments of Pharmacology, Chonnam University College of Dentistry) ;
- Ju, Jeong-Min (Departments of Pharmacology, Chonnam University Medical School) ;
- Shin, Dong-Ho (Departments of Pharmacology, Chonnam University College of Veterinary Medicine) ;
- Cho, Han-Ho (Departments of Pharmacology, Chonnam University, Medical School) ;
- Choi, Bong-Kyu (College of Medicine, Wonkwang University) ;
- Kim, Jae-Ha (Departments of Pharmacology, Chonnam University Medical School)
- 발행 : 1998.06.21
초록
Diazepam is known to have cardiovascular depressive effects through a combined action on benzodiazepinergic receptor and the GABA receptor-chloride ion channel complex. Moreover, it is known that barbiturates also have some cardiovascular regulatory effects mediated by the central GABAergic system. Therefore, this study was undertaken to delineate the regulatory actions and interactions of these systems by measuring the responses of the cardiovascular system and renal nerve activity to muscimol, diazepam and pentobarbital, administered intracerebroventricularly in rabbits. When muscimol