The Korean Journal of Physiology and Pharmacology
- 제2권2호
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- Pages.193-199
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Contractile Effects of Hemoglobin-Free Human Cerebrospinal Fluid on Isolated Porcine Cerebral Arteries
- Baik, Yung-Hong (Department of Pharmacology, Chonnam University Medical School) ;
- Kang, Seon-Young (Department of Pharmacology, Chonnam University Medical School) ;
- Kook, Hyun (Department of Pharmacology, Chonnam University Medical School) ;
- Chyung, Sang-Keun (Department of Pharmacology, Chonnam University Medical School) ;
- Kook, Young-Johng (Department of Pharmacology, Chonnam University Medical School) ;
- Kang, Sam-Suk (Department of Neurosurgery, Research Institute of Medical Sciences, Chonnam University Medical School)
- Published : 1998.04.21
Abstract
To elucidate the mechanism involved in the cerebral vascular spasm following subarachnoid hemorrhage (SAH), the effects of the cerebrospinal fluid (CSF) obtained from the SAH patients on the resting tension and its influence on the contractile responses to various vasoactive agents and to hypoxia were investigated in isolated porcine cerebral arteries. All the CSFs containing hemoglobin (Hb) produced contraction and some Hb-free CSFs also elicited contraction. When the Hb-free CSF was separated by microfilter, the filtrate of <30,000 MW did not produce contraction, while the fraction above 30,000 MW elicited more marked contractile responses than the unfractionated CSF. The CSF contraction was significantly attenuated in the presence of indomethacin or nimodipine, whereas the contractions induced by KCl, prostaglandin
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