Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Failure to Support Associations of Neurotrophin-3(NT-3) Gene Polymorphism in Korean Schizophrenic Patients

  • Lee, Yu-Sang (Yong-In Psychiatric Research Institute, Yong-In Mental Hospital) ;
  • Han, Jin-Hee (Department of Psychiatry, Catholic University of Korea and St. Vincent Hospital) ;
  • Chung, Eun-Kee (Seoul National Mental Hospital) ;
  • Yang, Byung-Hwan (Department of Psychiatry, College of Medicine and Mental Health Research Institute, Hanyang University) ;
  • Kim, Hyeong-Seob (Yong-In Psychiatric Research Institute, Yong-In Mental Hospital) ;
  • Lee, Jung-Sik (Yong-In Psychiatric Research Institute, Yong-In Mental Hospital) ;
  • Joo, Yeon-Ho (Yong-In Psychiatric Research Institute, Yong-In Mental Hospital) ;
  • Chai, Young-Gyu (Department of Biochemistry and Molecular Biology, Hanyang University)
  • Published : 1997.12.25
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Abstract

Though initial report from Japan showed positive association of schizophrenia with dinucleotide repeat polymorphism in the NT-3 gene, subsequent studies showed mixed results. Therefore we conducted a replication study with Korean schizophrenics and matched controls who share similar ethnic background with Japanese population. The frequency of allele of dinucleotide repeat at 147 base pairs in the NT-3 gene was slightly increased, however, failed to reach statistical significance(${\chi}^2$=1.884, df=1, p<0.170) between the two groups. These findings do not support an association of NT-3 gene polymorphism with schizophrenia in Korean sample.

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