생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제4권1호
  • /
  • Pages.48-53
  • /
  • 1997
  • /
  • 1225-8709(pISSN)
  • /
  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

도파민 발현 세포주 CV(bDAT) 세포에서 항정신병 약물이 도파민 수송체 활성에 미치는 영향

Effect of Antipsychotic Drugs on Dopamine Transporter Function in CV(bDAT) Cells

  • 김영미 (한양대학교 의과대학 생화학교실) ;
  • 이용성 (한양대학교 의과대학 생화학교실) ;
  • 이상훈 (한양대학교 의과대학 생화학교실) ;
  • 오동렬 (국립서울정신병원) ;
  • 양병환 (한양대학교 정신건강연구소 및 의과대학 신경정신과학교실) ;
  • 조석신 (한양대학교 의과대학 핵의학교실) ;
  • 남정현 (한양대학교 정신건강연구소 및 의과대학 신경정신과학교실)
  • Kim, Young-Mi (Department of Biochemistry, College of Medicine, Hanyang University) ;
  • Lee, Yong-Sung (Department of Biochemistry, College of Medicine, Hanyang University) ;
  • Lee, Sang-Hun (Department of Biochemistry, College of Medicine, Hanyang University) ;
  • Oh, Dong-Yul (National Seoul Mental Hospital) ;
  • Yang, Byung-Hwan (Department of Neuropsychiatry, College of Medicine & Mental Health Research Institute, Hanyang University) ;
  • Cho, Suck-Shin (Department of Nuclear Medicine, College of Medicine, Hanyang University) ;
  • Nam, Jung-Hyun (Department of Neuropsychiatry, College of Medicine & Mental Health Research Institute, Hanyang University)
  • 발행 : 1997.06.25
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초록

CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake activity were investigated. All of antipsychotic drugs tested, inhibited the [$^3H$]dopamine uptake into CV(bDAT) cells with $IC_{50}s$ in the low to mid micromolar range, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.

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