BMB Reports
- 제30권4호
- /
- Pages.246-252
- /
- 1997
- /
- 1976-670X(eISSN)
CoA Transferase and Malonyl-CoA Decarboxylase Activity of Malonate Decarboxylase from Acinetobacter calcoaceticus
- Byun, Hye-Sin (Department of Biochemistry, College of Science, Bioproducts Research Center, Yonsei University) ;
- Kim, Yu-Sam (Department of Biochemistry, College of Science, Bioproducts Research Center, Yonsei University)
- 투고 : 1997.04.17
- 발행 : 1997.07.31
초록
Malonate decarboxylase from Acinetobacter calcoaceticus is shown to have malonyl-CoA: acetate CoA transferase. acetyl-CoA: malonate CoA transferase, and malonyl-CoA decarboxylase activity. These enzyme activities were elucidated by isotope exchange reactions. The enzyme modified by N-ethylmaleimide completely lost its malonate decarboxylase activity, whereas it still kept CoA transferases and malonyl-CoA decarboxylase activities. The existence of CoA transferases and malonyl-CoA decarboxylase activity is clear, but their physiological significance is obscure. The catalytic reactions for two eoA transfers and malonyl-CoA decarboxylation proceed via a cyclic mechanism, which is through two covalent intermediates, enzyme-Smalonyl and enzyme-S-acetyL proposed for malonate decarboxylation of the enzyme.
키워드