BMB Reports

Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
권호 표지

Multiple Age-Associated Mitochondrial DNA Deletions in Mouse Brain

  • Kim, Jin-Sun (Department of Biology, Sookmyung Women's University) ;
  • Kim, Min-Jung (Department of Biology, Sookmyung Women's University) ;
  • Kwon, In-Sook (National Institute of Agricultural Science and Technology. Division of Molecular Genetics) ;
  • Song, Eun-Sook (Department of Biology, Sookmyung Women's University)
  • Received : 1996.10.29
  • Published : 1997.01.31
Download PDF
⟨ Previous Next ⟩

Abstract

Age-dependent deletion of mitochondrial DNA (mtDNA) was detected in mouse brain using PCR method. The size of the deleted fragment was 0.5 kb, 0.9 kb. 1.7 kb and 4.3 kb in the region between cytochrome b gene and ATPase 6 gene. The deleted fragment was increased gradually from 3-month to 22month Direct repeat sequence flanking the deletion in 0.5 kb PCR product was TAAT.

Keywords

References

  1. Mut. Res. v.250 Ames, B.N.;Gold, L.S. https://doi.org/10.1016/0027-5107(91)90157-J
  2. Mut. Res. v.275 Arnheim, N.;Cortopassi, G. https://doi.org/10.1016/0921-8734(92)90020-P
  3. Cell v.26 Bibb, M.J.;van Etten, R.A.;Wright, C.T.;Walberg, M.W.;Clayton, D.A. https://doi.org/10.1016/0092-8674(81)90300-7
  4. Aging Clin. Exp. Res. v.6 Chung, S.S.;Weindruch, R.;Schwarze, S.R.;McKenzie, D.I.;Aiken, J.M. https://doi.org/10.1007/BF03324239
  5. Nature Genetics v.2 Corral-Debranski, M. https://doi.org/10.1038/ng1292-324
  6. Mut. Res. v.275 Corral-Debranski, M.;Shoffner, J.M.;Lott, M.T.;Wallace, D.C. https://doi.org/10.1016/0921-8734(92)90021-G
  7. Nucleic Acids Res. v.18 Cortopassi, G.A.;Arnheim, N. https://doi.org/10.1093/nar/18.23.6927
  8. J. Am. Geriatr. Soc. v.20 Harman, D. https://doi.org/10.1111/j.1532-5415.1972.tb00787.x
  9. Biochem. Biophys. Res. Commun v.170 Ikebe, S. https://doi.org/10.1016/0006-291X(90)90497-B
  10. Naturwissenschaften v.77 Kadenbach, B. https://doi.org/10.1007/BF01138485
  11. Mut. Res. v.275 Linnane, A.W.;Zhang, C.;Baumer, A.;Nagley, P. https://doi.org/10.1016/0921-8734(92)90023-I
  12. Ann. Neurol. v.34 Mecocci, P.;Macgarvey, U.;Kaufman, A.E.;Koontz, D.;Shoffner, J.M.;Wallace, D.C.;Beal, M.F. https://doi.org/10.1002/ana.410340416
  13. Nucleic Acids Res. v.18 Mita, S.;Rizzuto, R.;Moraes, C.T.;Shanske, S.;Arnaudo, E.;Fabrizi, G.M.;Koga, Y.;DiMauro, S.;Schon, E.A. https://doi.org/10.1093/nar/18.3.561
  14. Exp. Gerontol. v.30 Ozawa, T. https://doi.org/10.1016/0531-5565(94)00057-A
  15. Am. J. Respir. Cell. Mol. Biol. v.6 Torii, K.;Sugiyama, S.;Takagi, K.;Satake, T.;Ozawa, T. https://doi.org/10.1165/ajrcmb/6.1.88
  16. Cell v.55 Wallace, D.C.;Zhang, X.;Lott, M.T.;Shoffner, J.M.;Hodge, J.A.;Kelley, R.I.;Epstein, C.M.;Hopkins, L.C. https://doi.org/10.1016/0092-8674(88)90218-8
  17. Biochem. Biophys. Res. Commun. v.164 Yuzaki, M.;Ohkoshi, N.;Kanazawa, I.;Kagawa, Y.;Ohta, S. https://doi.org/10.1016/0006-291X(89)91818-4
  18. Gene Anal. Tech. v.5 Zimmerman, E.G.;Akins, D.R.;Planz, J.V.;Schurr, M.J.