Clinical and Experimental Reproductive Medicine
- Volume 24 Issue 3
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- Pages.355-359
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- 1997
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
The Effect of Interferon-${\alpha}$ and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells
자궁근종과 자궁평활근 세포분열에 있어 Interferon-${\alpha}$ 및 basic Fibroblast Growth Factor (bFGF)의 효과
- Lee, B.S. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Park, J.S. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Kim, J.Y. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Bae, S.W. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Park, K.H. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Cho, D.J. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Lee, K.d (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Kim, J.W. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
- Song, C.H. (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University)
- 이병석 (연세대학교 의과대학 산부인과학교실) ;
- 박정식 (연세대학교 의과대학 산부인과학교실) ;
- 김진영 (연세대학교 의과대학 산부인과학교실) ;
- 배상욱 (연세대학교 의과대학 산부인과학교실) ;
- 박기현 (연세대학교 의과대학 산부인과학교실) ;
- 조동제 (연세대학교 의과대학 산부인과학교실) ;
- 이국 (연세대학교 의과대학 산부인과학교실) ;
- 김재욱 (연세대학교 의과대학 산부인과학교실) ;
- 송찬호 (연세대학교 의과대학 산부인과학교실)
- Published : 1997.12.30
Abstract
Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-