The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
권호 표지

Continuous Antiemetic Effects of Single Intravenous Injection of Antiemetics during Postoperative Pain Control with Morphine

Morphine 정주를 이용한 술후 통증 조절시 진토제 일회 정주의 지속적 항오심 및 항구토 효과

  • Choi, Gi-Sun (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • An, Chi-Hong (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Park, Sung-Sik (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Lim, Dong-Geon (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Baek, Woon-Yi (Department of Anesthesiology, School of Medicine, Kyungpook National University) ;
  • Park, Jin-Woong (Department of Anesthesiology, School of Medicine, Kyungpook National University)
  • 최기선 (경북대학교 의과대학 마취과학교실) ;
  • 안치홍 (경북대학교 의과대학 마취과학교실) ;
  • 박성식 (경북대학교 의과대학 마취과학교실) ;
  • 임동건 (경북대학교 의과대학 마취과학교실) ;
  • 백운이 (경북대학교 의과대학 마취과학교실) ;
  • 박진웅 (경북대학교 의과대학 마취과학교실)
  • Published : 1997.05.31
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Abstract

Background : This study was designed to evaluate the continuous effects of single intravenous injection of antiemetics on nausea and vomiting during continuous morphine injection for postoperative pain control. Methods : Prior to the study, we divided patients into two major groups according to the type of surgery performed intra-abdominal(Open: O) and non intra-abdominal(Close: C). When patients regained orientation after routine general anesthesia, enflurane-$O_2-N_2O$, we injected bolus dose of morphine and started continuous injection of morphine for postoperative pain control(Group I; Control). After bolus injection and just before continuous injection, we injected single dose of droperidol(Group II) or ondansetron(Group III). Mean arterial blood pressure, heart rate, pain score and symptom-therapy score were checked at 10 minutes, 4, 8, 16, 24, 36 hours after continuous morphine injection. Results : The pain score of group III was lower than group II(10 min.) and group I(24, 36 hours) in the open group. Symptom-therapy score of group III(10 min., 4, 24 hours) and group II(10 min.) were lower than group I in the open group. In the close group, symptom-therapy score of group III(8 hours) was lower than group I. Conclusions : Single intravenous injection of antiemetics have a tendency of lowering symptom-therapy score for 36 hours in spite of their relatively short elimination half-life.

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