진행된 상악동암의 병용치료

Combination Therapy for Advanced Maxillary Sinus Cancers

  • 조승호 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 김형태 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 김민식 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 김훈교 (가톨릭대학교 의과대학 내과학교실) ;
  • 윤세철 (가톨릭대학교 의과대학 치료방사선과학교실) ;
  • 김인아 (가톨릭대학교 의과대학 치료방사선과학교실) ;
  • 유우정 (가톨릭대학교 의과대학 이비인후과학교실) ;
  • 김성원 (가톨릭대학교 의과대학 이비인후과학교실)
  • Cho Seung-Ho (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, School of Medicine) ;
  • Kim Hyung-Tae (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, School of Medicine) ;
  • Kim Min-Sik (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, School of Medicine) ;
  • Kim Hoon-Kyo (Department of Internal Medicine, The Catholic University of Korea, School of Medicine) ;
  • Yoon Sei-Chul (Department of Therapeutic Radiology, The Catholic University of Korea, School of Medicine) ;
  • Kim In-Ah (Department of Therapeutic Radiology, The Catholic University of Korea, School of Medicine) ;
  • Yoo Woo-Jeong (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, School of Medicine) ;
  • Kim Sung-Won (Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, School of Medicine)
  • 발행 : 1997.11.01

초록

Background: Cancers of the maxillary sinuses are not common and are the most difficult head and neck malignancies in which to make an early diagnosis. Objectives: This reports was conducted to evaluated the efficacy of combination therapy and the relationship between the treatment modalities and their outcome of maxillary sinus cancers. Materials and Methods: We retrospectively analyzed a clinical datas of 46 patients who were treated at the department of Otolaryngology-Head and Neck Surgery. The Catholic University of Korea over 10 years between 1987 and 1996. Results: According to AJCC TNM system, 35 patients presented with $T_4$, 10 with $T_3$, one with T1. Two patients were treated with radiotherapy alone, 4 patients with chemotherapy alone, 17 patients with radiotherapy and chemotherapy, 23 patients with combination of surgery, radiotherapy and chemotherapy. The overall 5 years survival rate for combination therapy group were 57%, but 23 patients treated with the other treatment modalities all died within 2 years except two cases with chemotherapy and radiotherapy or radiotherapy alone. There was a statistical trend for better survival and local control in those patients treated with combination therapy than others(p<0.05). Conclusion: The results of this study suggest that it may be possible to acheive better results with aggressive combination treatment including surgery in advanced cases and to avoid orbital excentration in patients with orbital invasion.

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