대한수의학회지 (Korean Journal of Veterinary Research)
- 제37권2호
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- Pages.291-299
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- 1997
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
돼지와 랫트에서 sulfamethazine의 약물동태학 및 조직분포
Pharmacokinetic profile and tissue distribution of sulfamethazine in pigs and rats
- Yun, Hyo-in (College of Veterinary Medicine, Chungnam National University) ;
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Park, Seung-chun
(College of Veterinary Medicine, Chungnam National University) ;
- Oh, Tae-kwang (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- Cho, Joon-hyoung (Veterinary Research Institute) ;
- Park, Jong-myeong (Veterinary Research Institute)
- 투고 : 1996.08.17
- 발행 : 1997.06.25
초록
In order to establish optimal dosage schedules and withdrawal times for sulfamethazine(SMZ) in pigs, pharmacokinetic and tissue distribution experiments were conducted in pigs. For comparative purposes, tissue depletion kinetics are also studied in rats. From three pigs administered with SMZ i.v., the pharmacokinetic profile of SMZ in two pigs was adequately described by a one-compartment open model whereas that in one pig was patterned after a two-compartment open model. Volume of distribution(Vd) was 0.48~0.57 L/kg and biological half-life(