한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)
- 제14권2호
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- Pages.93-102
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- 1997
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- 1225-9098(pISSN)
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- 2288-1069(eISSN)
DOI QR Code
Isothiazoline 유도체의 합성 및 정제에 관한 연구
A Study on the Synthesis and Refining of Isothiazoline Derivatives
- Sung, Ki-Chun (Dept. of chemical engineering, Dae Jin University) ;
- Kim, Ki-Jun (Dept. of chemical engineering, Dae Jin University)
- 발행 : 1997.08.31
초록
Isothiazoline derivatives is widely used to food, medical drug and industrial goods, cosmetics etcs, and it makes to restrain and to sterilize a breeding of microbe as a preservative and a sterilizing agent. It differs with the raw material of paraoxybenzoic acid derivatives or imidazolydinyl urea to be in use at present, on the efficacy and effect, and has various characteristics. This synthesis makes 3,3'-dithiodipropionic chloride to add a thionyl chloride in 3,3'-dithiodipropionic acid, and 3,3'-dithiodipropionic methyl amide makes to synthesize in a reflux reaction the mono methyl amine to 3,3'-dithiodipropionic chloride. And last synthesis becomes to make chlorination-cyclization molecule doing a reflux reaction in the temperature of
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