Journal of Yeungnam Medical Science
- 제14권2호
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- Pages.350-358
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- 1997
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- 2799-8010(eISSN)
체외순환전 투여된 Thiopental이 Beta-endorphin치 변화에 미치는 영향
Thiopental Prevents A Beta-Endorphin Response to Cardiopulmonary Bypass
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송선옥
(영남대학교 의과대학 마취과학교실) ;
- ;
- 박대팔 (영남대학교 의과대학 마취과학교실) ;
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지대림
(영남대학교 의과대학 마취과학교실) ;
-
김세연
(영남대학교 의과대학 마취과학교실)
-
Song, Sun-Ok
(Department of Anesthesiology, College of Medicine, Yeungnam University) ;
- Carr, Daniel B. (Department of Anesthesiology, New England Medical Center) ;
- Park, Dae-Pal (Department of Anesthesiology, College of Medicine, Yeungnam University) ;
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Jee, Dae-Lim
(Department of Anesthesiology, College of Medicine, Yeungnam University) ;
-
Kim, Sae-Yeon
(Department of Anesthesiology, College of Medicine, Yeungnam University)
- 발행 : 1997.12.30
초록
수술에 의해 발생되는 침해성 통증이나 혈역학적 변화 및 내분비계의 반응은 마취 방법에 따라 약화되거나 조정될 수 있다. 본 연구는 심장수술시 체외순환 직전에 sodium thiopental을 투여한 경우 beta-endorphin치 변화에 미치는 영향을 관찰하고자 시행되었다. 관상동맥 우회술과 판막치환술을 위한 체외순환 환자 28명을 대상으로 하였다. Isoflurane,
We studied the effects of adding a single bolus(500 mg) of sodium thiopental to a continuous infusion of low-dose fentanyl on plasma beta-endorphin immunoreactivity(iBE) responses to cardiopulmonary bypass(CPB) in 28 patients undergoing elective coronary artery bypass grafting or valve procedures. Thiopental was injected just prior to the initiation of CPB. The iBE levels and the hemodynamic indices such, as mean arterial pressure, cardiac output and systemic vascular resistance were measured before CPB, at 30 min and again at 60 min after the initiation of the bypass. The results were as follows. After the initiation of CPB, iBE levels increased at 30 min and 60 min(P=0.006, P=0.004 respectively) in the control group, but not in the thiopental group. There were significant differences in the changes of iBE levels between the groups(F=8.7, G-G=0.002, P=0.001). The hemodynamic indices were similar in both groups. In conclusion, pretreatment with thiopental just before the initiation of CPB prevents the stress-induced beta-endorphin response to CPB.