Korean Journal of Environmental Agriculture (한국환경농학회지)
- Volume 16 Issue 1
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- Pages.61-66
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- 1997
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- 1225-3537(pISSN)
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- 2233-4173(eISSN)
Textural Changes in Rat Tissues by Carbofuran and Its Suppression by Phenobarbital Sodium and 3-Methylcholanthrene
Carbofuran이 쥐의 조직에 미치는 형태적 변화와 Phenobarbital Sodium 및 3- Methylcholanthrene에 의한 억제효과
- Rim, Yo-Sup (Dept. of Agricultural Chemistry, Wonkwang University) ;
- Han, Seong-Soo (Dept. of Agricultural Chemistry, Wonkwang University)
- Published : 1997.03.31
Abstract
This study was carried out to investigate the toxicological effects of carbofuran on the histological and fine structures in the kidney, liver, and brain of rat and also to clarify compensatory effects of phenobarbital sodium (PB) and 3-methylcholanthrene(3-MC) on the carbofuran toxicity. SPF albino rats were treated with carbofuran(3.8mg/kg), PB(60mg/kg), 3-MC(60mg/kg), carbofuran+PB, carbofuran+3-MC and subjected to the light microscopic study. In the kidney of rat, hemorrhage and extremely atropic change of renal corpuscles were frequently observed at 48 hrs after carbofuran treatment. Combination treatment groups of carbofuran and PB or 3-MC showed atrophic changes were largely recovered at 6 hrs, and the tissue findings of the kidney became similar to those of control group at 48 hrs after treatment. In the liver of rat treated only carbofuran, the degenerative and necrotic changes of hepatic lobules were frequently observed at 48 hrs after carbofuran treatment. Combination treatment of carbofuran and PB or 3-MC showed the hepatic lobules were similar to those of control groups at 6 hrs after the combination treatment. In the brain of rat treated with carbofuran alone, degenerative changes and dilation of capillary vessel of cerebral cortexes were observed at 48hrs after treatment. Combination treatment of carbofuran and PB or carbofuran and 3-MC showed the cerebral cortexes were similar to those of control groups at 6 hrs after the treatment. These results suggest that PB and 3-MC could regenerate the toxicity of carbofuran to the tissue of kidney, liver and brain of rat.
본 연구는 carbofuran이 흰쥐의 신장, 간 및 뇌조직내 각종 세포의 미세구조에 미치는 독성을 비교
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