Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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A Case of Central Nervous System Toxicity Associated with Cyclosporine

Cyclosporine에 의한 중추신경계 독성 1례

  • Lee Do-Yoon (Department of Pediatrics, Yonsei University, Wonju College of Medicine) ;
  • NamGoong Mee-Kyung (Department of Pediatrics, Yonsei University, Wonju College of Medicine) ;
  • Kim Hwang-Min (Department of Pediatrics, Yonsei University, Wonju College of Medicine) ;
  • Lim Baek-Keun (Department of Pediatrics, Yonsei University, Wonju College of Medicine)
  • 이도윤 (연세대학교 원주의과대학 소아과학교실) ;
  • 남궁미경 (연세대학교 원주의과대학 소아과학교실) ;
  • 김황민 (연세대학교 원주의과대학 소아과학교실) ;
  • 임백근 (연세대학교 원주의과대학 소아과학교실)
  • Published : 1997.10.01
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Abstract

Cyclosporine is an immunosuppressant usually used to prevent renal transplantation rejection. Nephrotoxicity and hypertension are considered as the most frequent side effects of cyclosporine treatment. The neurotoxic effects of cyclosporine such as agitation, anxiety, delirium, depression and psychosis have recently been found. Methylprednisolone may increase as well plasma concentration of cyclosporine, which leads to side effects. Here we report a $Henoch-Sch\"{o}nlein$ nephritis patient treated with cyclosporine and methylprednisolone who has experienced psychosis including visual and auditory hallucination and convulsion.

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