YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Asymmetric Methylation Using a Novel Chiral Auxiliary

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  • Jung, Ju-Eun (College of Pharmacy, Sookmyung Women's University) ;
  • Kim, Hee-Doo (College of Pharmacy, Sookmyung Women's University)
  • 정주은 (숙명여자대학교 약학대학) ;
  • 김희두 (숙명여자대학교 약학대학)
  • Published : 1997.12.01
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Abstract

We have synthesized and evaluated (1S, 2R)-1-0-(ethoxycarbonyl)methyl-2,3-0-isopropylidene-1-phenyl-1,2,3-trihydroxypropane(5a) as a novel chiral auxiliary for opt ically active alpha-hydroxyesters.

Keywords

References

  1. Total Synthesis of Natural Products. The Chiron Approach Hanessian, S.
  2. Tetrahedron Lett. v.36 Stereodivergent approach to α-hydroxyacid involving substrate directed reduction of α-keto amides Pansare, S. V.;Ravi, G. R.
  3. Tetrahedron Lett. v.42 Synthesis of enantiomerically enriched atrolactic aicd and other α-hydroxy acids Frater, Gy.;Mller, U.;Gnther, W.
  4. Carbohydr. Res. v.128 The synthesis of 1,2,5,6-di-O-isopropylidene-D-man-nitol. A comparative study Kuszmann, J.;Tomori, E.;Meerwald, I.
  5. J. Org. Chem. v.56 Synthesis of 2,3-O-isopropylidene-D-glyceraldehyde in high chemical and optical purity. Observations on the development of a practical bulk process Schimid, C. R.;Bryant, J. D.;Dowlatzedah, M.;Philips, J. L.;Prather, D. E.;Schantz, R. D.;Sear, N. L.;Vianco, C. S.
  6. Synlett Highly diastereoselective addition to a chiral β. γ-unsaturated α-oxo ester with bromomagnesium trior-ganozincates Sugimura, H.;Watanabe, T.