YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Sesquiterpene Pyridine Alkaloids from Euonymus japonica

사철나무의 알칼로이드 성분

  • Ryu, Jae-Ha (College of Pharmacy, Sookmyung Women's University) ;
  • Eun, Jin-Hee (College of Pharmacy, Sookmyung Women's University) ;
  • Lee, So-Young (College of Pharmacy, Sookmyung Women's University) ;
  • Chang, Joon-Shik (Division of Health Related Industry, Ministry of Health and Welfare) ;
  • Park, Man-Ki (College of Pharmacy, Seoul National University) ;
  • Park, Jeong-Hill (College of Pharmacy, Seoul National University) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University)
  • 류재하 (숙명여자대학교 약학대학) ;
  • 은진희 (숙명여자대학교 약학대학) ;
  • 이소영 (숙명여자대학교 약학대학) ;
  • 장준식 (보건복지부 보건산업담당관실) ;
  • 박만기 (서울대학교 약학대학) ;
  • 박정일 (서울대학교 약학대학) ;
  • 한용남 (서울대학교 천연물과학연구소) ;
  • 한병훈 (서울대학교 천연물과학연구소)
  • Published : 1997.10.01
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Abstract

Two alkaloidal components were isolated from the ether soluble part of the MeOH extract of the root bark of Euonymus japonica. Their structures were elucidated by the spe ctroscopic analylses as the sesquiterpene pyridine alkaloids derived from polyester sesquiterpenes which are characteristically detected in Celastraceae plants. These include macrocycle formed by two ester linkages between dihydro-${\beta}$-agarofuran nucleus and pyridinic dibasic acid(compound 1:evoninic acid, compound 2:wilfordic acid). The structure of compound $1[C_{47}H_{50}N_2O_{17},\;mp\;161{\sim}163^{circ}C$. $[{\alpha}]_D^{28}=+31.6^{\circ}$(c, 0.1 in EtOH)] was determined as novel structure named as euojaponine N, and compound $2[C_{48}H_{57}NO_{18},\;mp\;142{\sim}145^{circ}C,\;[{\alpha}_D^{27}=+27.0^{\circ}$(c, 0.1 in EtOH)] was identified as ebenifoline W-I reported from Maytenus ebenifolia.

Keywords

References

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