약학회지 (YAKHAK HOEJI)

  • 제41권4호
  • /
  • Pages.484-491
  • /
  • 1997
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

고탄수화물 식이 투여 마우스에서 상엽 컬럼분획물의 ${\alpha}$-glycosidase 활성에 미치는 영향

Effect of Mori Folium Column Fraction on Intestinal ${\alpha}$-glycosidase Activity in Mice Administered with a High Carbohydrate-Containing Diet

  • 정성현 (경희대학교 약학대학) ;
  • 김미선 (경희대학교 생활과학부 식품영양학과) ;
  • 조여원 (경희대학교 생활과학부 식품영양학과)
  • 발행 : 1997.08.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The effect of prolonged treatment with Mori Folium column fraction(MFCF) on intestinal ${\alpha}$-glycosidase activity has been studied in mice made hyperglycemic and hyperinsulinemic by feeding a high carbohydrate-containing diet. Mice were treated for 10 week with or without MFCF, added to the high carbohydrate-containing diet at 50mg/100g food. While MFCF had no effect on body weight, it prevented the rise in glycemia and insulinemia. Maltase, sucrase and lactase activities were measured in intestinal homogenates of proximal, middle and distal segments of jejunoileum. Following 10 week of MFCF administration, MFCF significantly induced all three enzyme activities especially at middle and distal segments. The mechanisms responsible for these changes and their potential biochemical implications remain to be determined.

키워드

참고문헌

  1. 당뇨병 v.19 당뇨병의 역학:예방을 위한 기본 이홍규
  2. Diabetes v.40 β-Cell in type Ⅱ diabetes mellitus Port, D.
  3. Diabetologia v.38 Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: in divorce possible> Cerasi, E.
  4. Front Hormone Res v.7 Pharmacolgy of a glucosidase inhibitor Puls, W.;Keup, U.;Krause, H.P.;Muller, L.;Schmidt, D.D.;Thomas, G.;Truscheit, E.
  5. Pharmacol. Biochem. Behavior v.19 Effects of a glucosidase inhibitor(Acarbose, BAY g 5421) on the development of obesity and food motivated behavior in Zucker(fafa) rat Vasselli, J.R.;Haraczkiewicz, E.;Maggio, C.A.;Greenwood, M.R.C.
  6. 약학회지 v.39 상업의 혈당강하 활성 정성현;이주선;최명현
  7. 유전공학논문집 v.8 상엽수층의 흰쥐소장 α-glycosidase 억제활성 정성현;최명현;류정화
  8. Carbohydrate Research v.284 Calystegin N1, a novel nortropane alkaloid with a bridgehead amino group from Hyspsyamus niger: Structure determination and glycosidase inhibitory activities Asano, N.;Nato, A.;Yokoyama, Y.;Miyauchi, M.;Yamamoto, M.
  9. J. Pharmacol. Exp. Ther. v.241 Inhibition of intestinal disaccharidase and supression of blood glucose by a new α-glycosidase inhibitor-MDL25. 637 Rhinehart, B.L.;Robinson, K.M.;Liu, P.S.;Payne, A.J.;Whetley, M.E.;Wagner, S.R.
  10. J. Med. Chem. v.37 Nitogen-in the-ring pyranose and furanose: Structural basis of inhibition of mammalian Asano, N.;Oseki, K.;Kizu, H.;Matsui, K.
  11. Anal. Biochem. v.72 A rapid and sensitive method of the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Bradford, M.
  12. Am. J. Physiol. v.286 Effect of genetic diabetes on enzymes of mouse intestinal brush-border mambrane Ramaswamy, K.;Flint, P.W.
  13. Diabetologia v.8 Increase of intestinal brush border hydrolases in mucosa of streptozotocin diabetic rats Caspary, W.F.;Rhein, A.M.;Creutzfeldt, W.
  14. J. Lab. Clin. Med. v.79 Effect of diabetes on intestinal disaccharidase activity Younoszai, M.K.;Schedl, H.P.
  15. Fed. Proc. (Abstract) v.37 Transport of monosaccharides by the small intestine of genetically diabetic mice Ramaswamy, K.;Peterson, M.A.