대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제27권1호
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- Pages.69-75
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- 1997
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- 1225-2344(pISSN)
핵산유도체들의 항 Human Immunodeficiency Virus in vitro 약효평가와 작용기전연구
In vitro Evaluation of Anti-Human Immunodeficiency Virus Activity of Nucleoside Derivatives and Studies on Their Mode of Action
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이종교
(한국화학연구소 의약활성연구실) ;
- 김동기 (한국화학연구소 의약활성연구실) ;
- 김지현 (한국화학연구소 의약활성연구실) ;
-
김해수
(한국화학연구소 의약활성연구실) ;
- 피미경 (한국화학연구소 의약활성연구실) ;
- 박종백 (한국화학연구소 의약활성연구실) ;
- 김백
-
Lee, Chong-Kyo
(Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Kim, Dong-Ki (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Kim, Jee-Hyun (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
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Kim, Hae-Soo
(Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Pi, Mi-Kyoung (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Park, Jong-Beak (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Kim, Baek (Department of Pathology, University of Washington)
- 발행 : 1997.06.30
초록
To evaluate in vitro anti-HIV efficacies of nucleoside derivatives, MT-4 cell line was infected with HIV-1 and HIV-2 respectively and treated with various compounds and the formerly approved drugs such as AZT, d4T, ddC and ddI. CPE method was used to evaluate their antiviral activity. Most dideoxynucleosides, AZT, d4T, ddC and ddI, showed anti-HIV activities against both viruses but no other compounds including anti-herpesvirus drugs did any. Further experiments were carried out to study their inhibitory mechanism of viral adsorption. The results showed no inhibition of syncytium formation due to an interaction between the gp120 expressed in HIV -infected cell surface and CD4 receptor on the uninfected cell surface in the presence of AZT. AZT showed no activity up to