대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제27권2호
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- Pages.227-237
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- 1997
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- 1225-2344(pISSN)
한약단미제 및 탕제의 항 Herpes Simplex Virus Type-1 활성탐색
Screening of Antiviral Activities of Korean Medicinal Herbs and Traditional Prescriptions Against Herpes Simplex Virus Type-1
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Kang, Bong-Joo
(Department of Basic Research, Korea Institute of Oriental Medicine) ;
- Yang, Ki-Sang (Department of Basic Research, Korea Institute of Oriental Medicine) ;
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Kim, Myung-Hee
(Department of Food and Culinary Arts, Suwon Women's College) ;
- Park, Kap-Joo (Department of Basic Research, Korea Institute of Oriental Medicine)
- 발행 : 1997.12.30
초록
향약집성방 및 동의보감등 한의학 서적을 기초로 하여 선택한 탕제 45종과 단미제 80종의 메탄올과 열수추출물을 가지고 MTT assay를 실시하여 항Herpes simplex virus-1 (HSV-1)에 대한 활성을 조사하였다. 열수추출 탕제 45종 중 백사전방, 현람방I, 현람방II, 반천청방 4종에서 항 HSV-1 활성을 나타냈고, 이들의 SI (selective index)값은
In order to search for anti-Herpes simplex virus (HSV) type-1 agents from Korean medicinal herbs and Korean traditional prescriptions (herb complexes), we selected 80 medicinal herbs and 45 prescriptions, based on a review of the Korean traditional medicine books. Both methanol extracts and boiling-water extracts were tested by means of the MTT assay (tetrazolium based colorimetric assay). Ten of the 125 methanol extracts: CM-11, CM-18, CM-19, CM-21, CM-22, CM-39, MM-3, MM-18, MM-29, MM-73 (see explanation of nomenclature below), showed efficacy against HSV-1. Twelve of the water extracts: CW-2, CW-3-I, CW-3-II, CW-18, MW-3, MW-5 MW-6, MW-12, MW-47, MW-69, MW-73 and MW-79 were active. #3 (individual herb) and #73 (individual herb) were interesting because both water and methanol extracts were active. Especially, #3 is a part of composition of Hong-il-