The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 31 Issue 1
- /
- Pages.83-89
- /
- 1997
- /
- 1225-6714(pISSN)
Role of PET in Evaluating Indeterminate Solitary Pulmonary Nodule with CT
CT상 악성여부가 불명확한 단일 폐결절에서의 양전자방출단층촬영술의 유용성
- Yoon, Seok-Boo (Departments of Nuclear Medicine, Samsung Medical Center) ;
- Choi, Joon-Young (Departments of Nuclear Medicine, Samsung Medical Center) ;
- Kim, Sun-Jung (Departments of Nuclear Medicine, Samsung Medical Center) ;
-
Choi, Yong
(Departments of Nuclear Medicine, Samsung Medical Center) ;
-
Choe, Yearn-Seong
(Departments of Nuclear Medicine, Samsung Medical Center) ;
-
Lee, Kyung-Han
(Departments of Nuclear Medicine, Samsung Medical Center) ;
-
Kim, Sang-Eun
(Departments of Nuclear Medicine, Samsung Medical Center) ;
-
Kwon, O-Jung
(Departments of Pulmonology, Samsung Medical Center) ;
-
Lee, Kyung-Soo
(Departments of Radiology, Samsung Medical Center) ;
- Kim, Byung-Tae (Departments of Nuclear Medicine, Samsung Medical Center)
- 윤석부 (삼성의료원 핵의학과) ;
- 최준영 (삼성의료원 핵의학과) ;
- 김선정 (삼성의료원 핵의학과) ;
-
최용
(삼성의료원 핵의학과) ;
-
최연성
(삼성의료원 핵의학과) ;
-
이경한
(삼성의료원 핵의학과) ;
-
김상은
(삼성의료원 핵의학과) ;
-
권오정
(삼성의료원 호흡기 내과) ;
-
이경수
(삼성의료원 진단방사선과) ;
- 김병태 (삼성의료원 핵의학과)
- Published : 1997.03.15
Abstract
About one-third of radiologically indeterminate solitary pulmonary nodules (SPN) are eventually turned out to be malignant. It is very important to noninvasively determine whether the SPN is malignant or not for the decision of its way of management. PET imaging is highlighted by its unique ability of imaging the function and metabolism of cells. Glucose metabolism is increased in malignant transformed cells. We peformed FDG-PET studies in patients who had radiologically indeterminate SPN and compared the findings with histologic diagnoses to assess the diagnostic accuracy in the detection of malignancy and to decide which parameter is the most suitable for clinical practice among peak SUV (pSUV), average SUV (aSUV), 50/10 ratio, and time-activity curve (TAC), Thirty patients were included in this study and the most useful parameter was pSUV. The sensitivity and specificity in the detection of malignant SPN using 3.5 as a cut off pSUV were both 87%. Interestingly, all 2 false-negative cases were bronch-ioloalveolar carcinoma on histologic examination. If these cases, which could be strongly suspected by CT findings, were excluded, the sensitivity of pSUV was 100%. In conclusion, PET imaging is very helpful for determining malignancy in indeterminate SPN and pSUV is a conveniently measurable parameter which is valuable for interpretation.
CT에서도 악성 여부가 불명확한 단일 폐결절의 감별진단에 있어 PET이 어떠한 도움을 줄 수 있는지 알아보고자 이러한 환자 30명을 대상으로 FDG-PET을 시행하여 각 환자에서 구한 pSUV, aSUV, TAC 양상, 50/10비의 4가지 매개변수를 조직검사결과와 비교하여 다음과 같은 성적을 얻었다. 1) 4가지 매개변수의 악성판정 기준치로
Keywords
- Indeterminate solitary pulmonary nodule;
- Positron emission tomography;
- Peak standardized uptake value;
- Time-activity curve