Biomedical Science Letters (대한의생명과학회지)
- Volume 3 Issue 2
- /
- Pages.71-76
- /
- 1997
- /
- 1738-3226(pISSN)
- /
- 2288-7415(eISSN)
Effects of Mitosene Analogues on Growth Inhibition of Human Cervical Cancer Cell Lines
Mitosene유사체의 자궁암세포주 성장억제 효과
- Dong-Soo Cha (Department of Obstetrics and Gynecology, Wonju College of Medicine, Yonsei University) ;
- Soo-Kie Kim (Department of Obstetrics and Gynecology, Wonju College of Medicine, Yonsei University) ;
- Chan-Mug Ahn (Department of Basic Sciences, Wonju College of Medicine, Yonsei University) ;
- Sun-Ju Choi (Department of Obstetrics and Gynecology, Wonju College of Medicine, Yonsei University) ;
- Yoon-Sun Park (Department of Microbiology, College of Medicine, Kwandong University) ;
- Sang-Won Han (Department of Obstetrics and Gynecology, Wonju College of Medicine, Yonsei University)
- Published : 1997.12.01
Abstract
To develop a promising alkylating agents for anti-cervical cancer chemotherapy, five mitosene analogues were synthesized. Despite the potentiality of better cytotoxicity on solid tumor cells as opposed to that on rapidly-doubled leukemic cells, there have been no reports on the inhibition of the cervical cancer cell line by mitosene analogues. The present experiment was designed to investigate whether mitosene analogues can effectively inhibit the cellular proliferation of cervical cancer cells by using an in vitro chemosensitivty system. The mitosene analogues displayed a potent cytotoxic effect on the tested cervical cancer cell lines. Among the analogues, (22) compound gave the best inhibitory effect on SiHa tumor colonies formation. These data indicate that mitosene analogues can effectively inhibit the growth of cervical cancer cells in vitro.
실험적 자궁암 치료제로서 본 연구소에서 합성한 마이토센유사체를 인체 자궁암세포주인 SiHa, C33A, HeLa, CaSki에 처리하여, 체외 항암활성 측정시 합성 마이토센유사체들은 이 들 세포주에 대하여 대조 항암제들에 비하여 의의있는 세포독성을 보였으며, SiHa 세포주를 이용한 종양클론형성 억제검사에서는 22번 화합물만이 종양성장 억제활성이 가장 우수하였고 다른 화합물들은 대조항암제들에 비하여 활성이 낮았다. 이 마이토센유사체들에 대한 체외 항암감수성결과는 향후 전임상적인 자궁경부암 화합요법제의 기초자료로 유용할것으로 생각된다.