Effect of Renal Denervation on Diuretic Action of UK 14,304, $\alpha$$_2$-Adrenergic Agonist, in Dog

$\alpha$$_2$-아드레날린 효능제인 UK 14,304의 이뇨작용에 대한 신장신경 제거의 영향

  • KO, Suk-Tai (Dept. of Pharmacology, College of Pharmacy, Chosun University) ;
  • NA, Han-Kwang (Dept. of Clinical Pharmacology, Toxicology Research Institute, Korea FDA)
  • 고석태 (조선대학교 약학대학 약물학교실) ;
  • 나한광 (식품의약품 안전본부, 독성연구소 약효약리과)
  • Published : 1997.12.01

Abstract

This study was performed in order to investigate the effect of renal denervation on diuretic action of UK 14, 304, $\alpha$$_2$-Adrenergic Agonist, administered into the vein and the carotid artery in dog. The diuretic action of UK 14, 304 administered into the vein or the carotid artery was reversed to the antidiuretic action by renal denervation, this time, the decrease of N $a^{+}$excretion amounts in urine ( $E_{Na}$ ) and the increase of N $a^{+}$ reabsorption rates in renal tubule ( $R_{Na}$ ) were exhibited. This results suggest that central diuretic action of UK 14, 304 is mediated by renal nerves and the antidiuretic action of UK 14, 304 in denervation kidney is caused by the increase of N $a^{+}$reabsorption rates ( $R_{Na}$ ) in renal tubules in dog.n dog.

Keywords