General Pharmacology of $\imath$--Muscone

$\imath$-Muscone의 일반약리작용

  • 이선미 (성균관대학교 약학대학) ;
  • 조태순 (성균관대학교 약학대학) ;
  • 심상호 (조선무약(자) 생명과학연구소) ;
  • 박석기 (조선무약(자) 생명과학연구소) ;
  • 홍채영 (조선무약(자) 생명과학연구소) ;
  • 김성수 (조선무약(자) 생명과학연구소) ;
  • 신대희 (조선무약(자) 생명과학연구소) ;
  • 김용기 (조선무약(자) 생명과학연구소) ;
  • 박대규 (조선무약(자) 생명과학연구소)
  • Published : 1997.09.01

Abstract

General pharmacological properties of ι-muscone, the major component of musk, were investigatedin mice, rats and guinea pig. The administration of ι-muscone (1, 10, 100 mg/kg, p.o.) in mice had no effects in general behaviors, and no influences on analgesic actions and normal body temperature. Muscle relaxant action, intestinal propulsion and gastric secretion were not observed even at the high dose of 100 mg/kg. ι-Muscone (1, 10, 100 mg/kg, p.o.) given to conscious rats showed no effect on mean blood pressure and heart rate. It showed no direct effect at 2.4$\times$10.3 mg/ml and 2.4$\times$10-2 mg/ml in isolated uterus of rats and ileum of guinea pig, and also had no inhibition of contraction induced by oxytocin and histamine.

Keywords