Journal of Sericultural and Entomological Science (한국잠사곤충학회지)

Korean Society of Sericultural Science (한국잠사학회)
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Effect of Silkworm Extract on Intestinal $\alpha$-Glycosidase Activity in Mice Administered with a High Carbohydrate-containing Diet

고탄수화물 식이투여 마우스에서 누에추출물이 소장내의 $\alpha$-glycosidase 활성에 미치는 영향

  • 정성현 (경희대학교 약학대학 약물학교실) ;
  • 김미선 (경희대학교 약학대학 약물학교실, 잠사곤충연구소) ;
  • 류강선
  • Published : 1997.06.01
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Abstract

The effects of silkworm extract on body weight, blood glucose and insulin levels, and an intestinal glycosidase activity were studied in high carbohydrate diet administered mice. Hyperglycemia and hyperinsulinemia represented in high carbohydrate diet administered mice disappeared when silkworm extract(50 mg) was added to 100 g diet for 10 week period. These results suggest that silkworm extract may resolve the insulin resistance by lowering serum insulin level resulting from inhibition of intestinal glycosidase activity. Silkworm extract coadministered with high carbohydrate diet to mice for 10 weeks significantly induced maltase, sucrase and lactase acivities, especially middle and distal portion. Further studies about regulatory mechanisms of glycosidase by silkworm extract are needed.

Keywords

References

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