Journal of Nutrition and Health

  • 제30권10호
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  • Pages.1153-1159
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  • 1997
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

비타민 E 보강식이가 KK 마우스에서 지질과산화물과 신장 항산화계 효소 활성도에 미치는 영향

Effects of Vitamin E Supplementation on Lipid Persoxides and Renal Antioxidative Enzyme Activities in KK Mice

  • 안현숙 (서울대학교 식품영양학과)
  • 발행 : 1997.12.01
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초록

We investigated the effects of vitamin E supplementation on lipid peroxidation and on the activities of antioxidative enzymes in kidney of KK mice of various age and duration of diabetes. Weaned KK mice were fed high fat a diet containing 20% corn oil(wt/wt), and were sacrificed at 4, 6, and 9 months of age. The high vitamin E diet consisted of the high fat diet supplemented with an excessive amount of dl-$\alpha$-tocopheryl acetate (2080 IU/kg diet) . In the diabetic groups, we found an increase in lipofuscin and decrease in antioxidative enzyme activities with aging. Treatment with vitamin E did not modify the level of fasting blood glucose. However, a significant decrease in lipofuscin and increase in antioxidative enzyme acitvities were observed in diabetic mice.

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