Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Preventive Effect of Selenium Supplementation on Iron Accumulation of Rats Fed Diets Containing High Levels of iron

철분의 과잉섭취시 셀레늄 섭취수준이 철분과잉 축적에 대한 예방효과에 관한 연구

  • 전예숙 (충남산업대학교 식품영양학과)
  • Published : 1997.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effect of selenium supplementation of iron accumulation of rats fed diets containing high levels or iron. Sixty male Sprague-Dawley weaning rats were fed with diets containing various levels of iron(adequate : 35ppm, 2-fold : 70ppm, 4-fold : 140ppm) and selenium(adequat : 0.05ppm and high : 0.05ppm) for 12 weeks. Feed intakes of 2-fold and 4-fold iron groups were higher than that of adequate iron group. There was no difference body weight gain across iron and selenium containing diet groups. Hemoglobin level was increasd with iron increment and decreased with selenium supplementation. Iron contents in serum and tissues were increased as iron intake was increased. Liver iron content was decreased with selenium supplementation. Selenium content in liver was decreased with iron increment and increased with selenium supplementation. In the case of iron balance, iron excretion through urine and feces was significantly increased as iron intake was increased. However, apparent absorbability and retention rate of iron were not significantly affected by dietary iron or selenium.

Keywords

References

  1. 사망통계연보 경제기획원조사통계국
  2. Am J Epidemiol v.127 Vitamin supplement use, by demographic characteristics Block,G.;Cox,C.;Madans,J.;Schreiber,C.B.;Licitra,L.;Melia,N.
  3. J Am Diet Assoc v.89 no.3 Vitamin and mineral supplementation practices of adults in seven western states Medeiros,D.M.
  4. 국민영양조사보고서 보건사회부
  5. 한국영양학회지 v.23 no.4 서울지역 성인의 영양보충제 복용실태 이상선;김미경;이은경
  6. 한국영양학회지 v.27 no.3 중년기의 비타민 · 무기질 보충제 복용실태 조사 김선효
  7. Nutr Res v.6 Mineral supplementation practices of adults in seven western states Read,M.H.;Medeiros,D.M.;Bendal,R.
  8. Am J Clin Nutr v.36 Nutritional status in a healthy elderly population : Dietary supplemental intakes Garry,P.J.;Goodwin,J.S.;Hunt,W.C.;Hooper,E.M.;Leonard,A.G.
  9. New Engl J Med v.286 Copper deficiency in an infant fed an iron-fortified formula Seely,J.R.;Humphrey,G.B.;Matter,B.J.
  10. Fed Proc v.42 Interaction of iron and zinc on bioavailability of each element in the rat Gordon,D.T.
  11. Lancet v.1 Iron and the sex difference in heart disease risk Sullivan,J.L.
  12. Ann Intern Med v.85 Menopause and the risk of cardiovascular disease;The Framingham study Kannel,W.B.;Hjortland,M.C.;McNamara,P.M.;Gordon,T.
  13. J Nutr v.117 Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes Cunnane,S.C.;McAdoo,K.R.
  14. Nutr Rev v.53 Iron overload-Prevalence and impact on health Lynch,S.R.
  15. Biochem Biophys Res Commun v.71 Glutathione peroxidase activity in selenium deficient rat liver Lawrence,R.A.;Burk,R.F.
  16. J Nutr v.107 AIN standards for nutrition studies report
  17. Nutrient requirements of laboratory animals National research council
  18. Science v.127 Hemoglobin standard Cannan,R.K.
  19. 식품과 영양 v.17 no.1 식품의 무기성분 분석 임정남
  20. SAS라는 통계상자 김충련
  21. J Anim Sci v.29 Influence of graded levels of dietary iron, as ferrous sulfate, on performance and tissue mineral composition of steers Standish,J.F.;Ammerman,C.B.;Simpson,C.F.;Neal,F.C.;Palmer,A.Z.
  22. 한국노화학회지 v.4 no.1 식이철분수준이 흰쥐의 혈장 및 조직의 미량원소 함량에 미치는 영향 윤태헌;김현숙
  23. 한국영양학회지 v.15 no.4 식이내 단백질과 철분수준이 흰쥐의 Fe, Cu 및 Zn 대사에 미치는 영향 정해랑;김미경
  24. J Nutr v.104 Effect of dietary copper, iron and ascorbic acid levels on hematology, blood and tissue copper, iron and zinc concentrations and $^{64}Cu$ and $^{59}Fe$ metabolism in young pigs Gipp,W.F.;Pond,W.C.;Kallfelz,F.A.;Tasker,J.B.;Van Campen,D.R.;Krook,L.;Visek,W.J.
  25. J Nutr v.121 Mucus and iron absorption regulation in rats fed various levels of dietary iron Wien,E.M.;Van Campen,D.R.
  26. J Anim Sci v.31 Effect of elevated dietary levels of iron on the performance of blood constituents of calves Koong,L.;Wise,M.B.;Barrick,E.R.
  27. J Nutr v.81 Effect of iron supplementation of sow rations on the prevention of baby pig anemia Chaney,C.M.;Barnhart,C.E.
  28. Am J Clin Nutr v.42 Does iron supplementation compromise zinc nutrition in healthy infants? Yip,R.;Reeves,J.D.;Lonnerdal,B.;Keen,C.L.;Dallman,R.P.
  29. Atherosclerosis v.36 Risk factors for ischaemic vascular death for men in the Stockholm prospective study Bottiger,L.E.;Carlson,L.A.
  30. Lancet v.4 Raised hemoglobin and risk of cardiovascular disease Cullen,K.J.;Stenhouse,N.S.;Waerne,K.L.
  31. Clin Haematol v.2 Diagnosis and clinical evaluation of iron overload Kaltwasser,J.P.;Werner,E.
  32. Circulation v.86 High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men Salonen,J.T.;Nyyssnen,K.;Korpela,H.;Tuomilehto,J.;Seppnen,R.;Salonen,R.
  33. Ann Nutr Metab v.33 Experimental selenium toxicity in Guinea pigs : Haematological studies Das,P.M.;Sadana,J.R.;Gupta,R.K.;Gupta,R.P.
  34. J Nutr v.120 Effect of dietary iron overload on lipid peroxidation, prostaglandin synthesis and lymphocyte proliferation in young and old rats Wu,W.H.;Meydani,M.;Meydani,S.N.;Burklund,P.M.;Blumberg,J.B.;Munro,H.N.
  35. J Nutr v.114 The ironzinc interrelationship in the chick as influenced by eimeria acerbulina infection Bafundo,K.W.;Baker,D.H.;Fitzgerald,P.R.
  36. J Clin Invest v.71 Hepatic lipid peroxidation in vivo in rats with chronic iron overload Bacon,B.R.;Tavill,A.S.;Brittenham,G.M.;Park,C.H.;Recknagel,R.O.
  37. CRC Crit Rev Clin Lab Sci v.19 Iron overload disorders : Natural history, pathogenesis, diagnosis and therapy McLaren,G.D.;Muir,W.A.;Kellermeyer,R.W.
  38. Arch Pathol Lab Med v.103 Iron and the liver;Subcellular distribution of iron and decreased microsomal cytochrome $P_{450}$ in livers of iron-loaded rats Bonkowsky,H.L.;Carpenter,S.J.;Healey,J.F.
  39. Ann Nutr Metab v.30 Effects of dietary selenium and vitamin E on plasma lipoprotein cholesterol levels in male rats Stone,W.L.;Stewart,M.E.;Nicholas,C.;Pavuluri,S.
  40. Ann Nutr Metab v.37 Effect of iron supplementation during pregnancy on trace element(Cu, Se, Zn) concentrations in serum and breast milk from Nigerian women Arnaud,J.;Prual,A.;Preziosi,P.;Cherouvrier,F.;Favier,A.;Galan,P.;Hercberg,S.
  41. J Nutr v.116 Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose Johnson,M.A.;Hove,S.S.
  42. J Anim Sci v.27 Effect of Na₂EDTA in diets of different iron levels of utilization of calcium, phosphorus and iron by rats Harmon,B.G.;Becker,D.E.;Jensen,A.H.;Norton,H.W.