Korean Journal of Veterinary Pathology (한국수의병리학회지)
- Volume 1 Issue 2
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- Pages.107-118
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- 1997
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- 1226-766X(pISSN)
A Study of Anticarcinogenic Effects of Allyl methyl Trisulfide and Methyl Propyl Disulfide on F344 Rats in a Rat Multi-organ Carcinogenesis Model
F344랫트를 이용한 다장기 발암모델에 나타난 Allyl Methyl Trisulfide와 Methyl Propyl Disulfide의 항발암효과
- Son, Hwa-Young (Korea Research Institute of Chemical Technology, Screening & Toxicolog Research Center) ;
- Kang, Boo-Hyon (Korea Research Institute of Chemical Technology, Screening & Toxicolog Research Center) ;
- Ha, Chang-Su (Korea Research Institute of Chemical Technology, Screening & Toxicolog Research Center) ;
- Roh, Jung-Koo (Korea Research Institute of Chemical Technology, Screening & Toxicolog Research Center)
- 손화영 (한국화학연구소 스크리닝-안전성연구 센터) ;
- 강부현 (한국화학연구소 스크리닝-안전성연구 센터) ;
- 하창수 (한국화학연구소 스크리닝-안전성연구 센터) ;
- 노정구 (한국화학연구소 스크리닝-안전성연구 센터)
- Published : 1997.12.01
Abstract
The anticarcinogenic effects of allyl methyl trisulfide(AMT) and methyl propyl disulfide(MPD) were studied in a 28 weeks rat multi-organ carcinogenesis model. Tumor incidence rate was decreased by AMT or MPD treatment comparing with the positive control. AMT treatment significantly decreased the incidence of neoplastic and preneoplastic lesions in the kidney thyroid gland urinary bladder alimentary tract lung and Zymbal's gland. MPD also inhibited incidence of noplastic and preneoplastic lesions in the liver kidney urinary bladder alimentary tract lung and Zymbal's gland but increased that in the thyroid gland. GST-p positive foci in the liver were slightly decreased by AMT or MPD. There was no significant histopathological lesions in AMT or MPD treated group without pretreatment of carcinogens.
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