한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제25권6호
  • /
  • Pages.586-591
  • /
  • 1997
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Streptomyces sp. 50634 균주가 생산하는 tipA Promotor 활성화 물질, Sulfomycin Ia

  • Shim, Yong-Ho (Korea Research Institute of Bioscience and Biotechnology) ;
  • Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology) ;
  • Seto, Haruo (Institute of Molecular and Cellular Biosciences, The University of Tokyo) ;
  • Hwang, Se-Young (Graduate School of Biotechnology, Korea University) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 1997.12.01
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초록

In the course of screening for the tipA promoter-inducing substances, we isolated an active compound, sulfomycin Ia, from the mycelium of a microorganism designated 50634. The producing organism was identified as Streptomyces sp. on the basis of taxonomic studies. Sulfomycin Ia was purified from mycelial extract by silica gel column chromatography, LH-20 column chromatography, silica gel TLC, and preparative HPLC. The molecular weight of sulfomycin Ia was determined to be m/z 1129 (M+Na)$^{+}$ by FAB mass measurement and $^{1}$H NMR spectroscopic analysis. The structure was assigned as a derivative of sulfomycin I with thiazole, methyloxazole, oxazole, and pyridine rings by $^{1}$H NMR spectral data.

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참고문헌

  1. Antibiotics Ann Thiostrepton, a new antibiotic Pagano,J.F.;M.J.Weinstein;H.A.Stout;R.Donovick
  2. Nature v.225 The structure of thiostrepton Anderson,B.;D.C.Hodgkin;M.A.Viswamitra
  3. J.Bacteriol. v.171 no.3 Thiostrepton induced gene expression in Streptomyces lividans Murakami,T.;T.G.Holt;C.J.Thompson
  4. EMBO J v.12 no.8 Autogenous transcriptional regulation of thiostrepton-induced gene in Streptomyces lividans Holmes,D.J.;J.L.Caso;C.J.Thompson
  5. Nature v.265 Structure of nosiheptide, a polythiazole-containing antibiotic Prange,T.;A.Ducruix;C.Pascard
  6. J. Am. Chem. Soc. v.99 no.19 Highly modified cystein-containing antibiotics, chemical structure and configuration of nosiheptide Pasard,C.;A.Ducruix;J.Lunel;T.Prange
  7. J. Am. Chem. Soc. v.99 no.5 Berninamycin 3. Total structure of Berninamycin A Liesch,J.M.;K.L.Rinehart,Jr.
  8. Tetrahedron Lett. v.29 no.12 The structures of sulfomycin I and berinamycin A Abe,H.;K.Kushida;Y.Shiobara;M.Kodama
  9. J. Antibiotics v.47 no.4 Promothiocins A and B, novel thiopeptide with tipA promoter inducing activity produced by Streptomyces sp. SF2741 Yun,B.S.;T.Hidaka;K.Furihata;H.Seto
  10. App. Microbial. v.28 no.16 Simplified approach to identification of aerobic actinomycetes by thinlayer chromatography Staneck,J.L.;G.D.Roberts
  11. Int. J. Syst. Bacteriol. v.16 Methods of characterization of Streptomyces species Shirling,E.B.;D.Gottlieb
  12. Bergey's manual of systematic bacteriology v.4 Williams,S.T.;M.E.Sharpe;J.G.Holt
  13. J. Antibiotics v.22 no.1 Sulfomycins, a series of new sulfur-containing antibiotics Egawa,Y.;K.Umino;Y.Tamura;M.Shimizu;K.Kaneko;M.Sakurazawa;S.Awataguchi;T.Okuda
  14. J. Antibiotics v.49 no.10 The structures of sulfomycin Ⅱ and Ⅲ Kohno,J.;N.Kaneda;M.Nishio;A.Kinumaki;S.Komatsubara