생명과학회지 (Journal of Life Science)

  • 제7권4호
  • /
  • Pages.276-281
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  • 1997
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

태서 중추신경계의 Heat Shock Protein 70 분포에 대한 Nicotine 영향

Immunohistochemical Localization of Heat Shock Protein 70 in the Central Nervous System of Nicotine-treated Rat Embryo

  • 발행 : 1997.12.01
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초록

This study was investigated to determine whether nicotine causes the morphological changes and expression of heat shock protein(HSP) 70 in the central nervous system of rat embryo. The pregnant rats were injected s.c. twice daily with 3 mg nicotine per 100g body weight from day 0 to 14 of gestation and embryos were removed on gestation day 15. As morphological changes, retardation of cell proliferaton was observed in the telencephalon of nicotine-treated groups and no changes in the other region were found. Minimal HSP 70 was expressed over chole central nervous system was similar between control and nicotine-treated group, the expression of blood cells in the meinges and chroid plexus was significantly greater in nicotine-treated group than in control.

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참고문헌

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