생명과학회지 (Journal of Life Science)

  • 제7권3호
  • /
  • Pages.234-240
  • /
  • 1997
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

인체암세포증식에 있어 십자화과 채소의 억제효과

lnhibitory Effect o fVarious Cruciferous Vegetable on the Growth of Human Cancer Calls

  • 발행 : 1997.09.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

부유세포인 K-562 임체 혈액암세포 및 부착세포인 인체 AGS 위암세포, HT-29 결장암세포 및 MG-63 골육암세포를 이용하여, 10종의 십자회과채소들로부터 추출한 메탄을 추출물의 암세포 성장저해효과를 연구하였다. 모든 십자화과 채소시료는 K-562 인체혈액암세포에 대히 70% 이상의 암세포 증식억제효과를 보였는 데, 특히 브로콜리가 92.9%의 증식억제효과를 나타내 가장 효고가 좋았다. 위암세포인 AGS세포에서는 모든 시료들이 50%이상의 암세포성장 억제효과를 가졌는데, 이 경우 케일, 브로콜리, 냉이가 각각 93.5%, 93.5%, 96.3%의 매우 높은 위암세포의 중식억제효과를 보였다. 또한 사람의 결장암 세포인 HT-29의 경우 양배추, 배추, 케일, 냉이가 각각 82.4%, 72.1%, 79.4%, 95.6$\mid$의 증식억제효과를 보였고, MG-63 골육암세포에 대해서는 케일, 냉이가 각각 79.2%, 88.7%로 가장 높은 저해효과를 보여 일반적으로 십자화과 채소들은 인체암 세포의 성장을 억제하는 것으로 나타났으나 그중 케일과 냉이가 가장 효과가 좋았다.

The anticarcingenic effect of methanol extracts from such cruciferous vegetables as cabbage, red cabbage, Korean cabbage, kale, cauliflower, broccoli, radish root, leafy radish, rape leaves and shepherd’s purse on the growth of human K-562 leukemia cells, MG-63 osteosarcoma cells, HT-29 colon cancer cells and AGS gastric cancer cells were studied. All of cruciferous vegetables inhibited more than 70% of the growth of K-52 leukemia cells and more than50% fo rhe growth fo AGS gastric cancer cells. Particularly, kale, broccoli and shepherd’s purse showed inhibition rates of 93.5%, 93,5% and 96.3% on the growth of AGS gastric cancer cells, respectively. In case of HT-29 colon cancer cells, the methanol extracts of cabbage, kale and shepherd’purse exhibited 82.4%, 72.15, 79.4% and 95.6% of inhibitory effects, respectively. The cabbage, kale, cauliflower and shepherd’s purse extracts also highly suppressed the proliferation of MG-63 cells. Generally the 10 cruciferous vegetable we studied strongly decreased the growth of various human cancer cells in vitro, however, kale and shepherd’s showed the most effective vegetable among them.

키워드

참고문헌

  1. 한국환경성돌연변이 발암원학회지 v.1 암의 원인과 환경. 윤택구
  2. J. Natl. Cancer Inst. v.66 The cause of cancer. Doll, R.;Peto, R.
  3. 한국영양식량학회지 v.14 no.3 식품, 영양과 암의 관계. 류태형
  4. Nippon Nogeikagaku Kaishi v.55 Recent research on environment mutagens. Kada, T.
  5. Agric. Biol. Chem. v.42 Studies on natural desmutagens : Screening for vegetable and fruit factors active in inactivation of mutagenic pyrolysis products from amino acid. Morita, K.:Hara, M.;Kada, T.
  6. Kor. J. Pharm. v.21 Assay of antimutagenic activities of vegetable plants. Seo, J. S.;Lee, Y. W.;Suh, N. J.;Chang, I. M.
  7. J. Nat. Prod. v.52 Plant antimutagenic agents : 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cympols from green alga (Cymopollia barbata). Wall, M. E.;Wani, M. C.;Manikumar, G.;Taylor, H.;Hughse, T. J.;Gaetano, K.
  8. J. Agric. Food Chem. v.35 High performance liquid chromato graphic analysis of anticarcinogenic indoles in Brassica oleracea. Bradifield, C. A.;Bjeldanes, L. F.
  9. Fd. Chem. Toxic. v.25 no.8 The effects of dietary cabbage on xenobiotic metabolizing enzymes and the binding of aflatoxin B₁to hepatic DNA in rats. Whitty, J. P.;Bjeldanes, L. F.
  10. Cancer Res. v.38 Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Wattenberg, L. W.;Loub, W. D.
  11. J. Natl. Cancer Inst. v.58 no.2 Inhigition of carcinogenic effects of polyclic hydrocarbons by benzyl isothiocyanate and related compounds. Wattenberg, L. W.
  12. J. Agric. Food Chem. v.37 Isolation of compounds with antimutagenic activity from savoy chieftain cabbage. Lawson, T.;Nunnally, J.;Walker, B.;Bresnick, E.;Wheeler, D.;Wheeler, M.
  13. Agric. Biol. Chem. v.53 no.3 Herb water-extracts markedly suppress the mutagenicity of Trp-P-2. Natake, M.;Kanazawa, K.;Mizuno, M.;Ueno, N.;Kobayashi, T.;Danno, G.;Mizuno, M.;Ueno, N.;Kobayashi, T.;Danno, G.;Minamoto, S.
  14. Cancer Res. v.48 Modulation of HT-29 human colonic cancer cell differentiation with calmidazolium and 12-o-tetradecanoyl-phorbol-13-acetate. Cecile, R. E.;Kedinger, M.;Haffen, K.
  15. J. Cell Physiol. v.123 1α, 25-dihydroxy vitamin D₃specific regulation of growth, morphology and fibronectin and a human osteosarcoma cell line. Franceschi, R. T.;James, W. M.;Zerlauth, G.
  16. 한국영양학회지 v.23 no.2 마늘 중 지용성 성분의 암세포 증식 억제 효과 연구. 손홍수;황우익
  17. J. Biol. Chem. v.24 The role of glycolysis in the growth of tumor cells. Goldburg, E.;Nitowsky, H.;Colowick, S.
  18. 한국영양식량학회지 v.21 no.4 참치추출물의 항암 및 면역효과. 황우익;백나경;황윤경;이성동
  19. Principles and practice of oncology updates v.3 no.10 Status of the NCI. Preclinical antitumor drug discovery screen. Boyd, M. R.;Devita, V.T.Jr.(ed.);Hellman, S(ed.).;Rosenberg, S.A.(ed.)
  20. J. Nat. Prod. v.55 Cytotoxic quassinoids from Cedronia granatensis. Tischler, M.;Cardellina Ⅱ., J. H.;Boyd, M. R.;Gragg, G. M.
  21. Cancer Chemother. Rep. v.3 Protocols for screening chemical agents and natural products against animal tumors and other biological system.(3rd edition) Green, R. I.;Green, N. H.;MacDonald, M. M.;Abbott, B. J.
  22. Methods in Cancer Research;Cancer Drug Development v.16 Historical development and current strategy of the National Cancer Institute drug development program. Goldin, A.;Schepartz, S. A.;Venditti, J. M.;DeVita, V. T.;Devita V.T.(ed.);Busch H.(ed.)
  23. Cancer Res. v.50 Characterization of cell lines established from human gastic carcinoma. Park, J. G.;Frucht, H.;LaRocca, R. V.;Bliss, D. P.;Kurita, Y.;Chen, T. R.;Henslee, J. G.;Trepel, J. B.;Jensen, R. T.;Johnson, B. E.;Bang, Y. J.;Kim, J. P.;Gazdar, A. F.
  24. Proc. Natl. Acad. Sci. USA v.89 A major inducer of anticarcinogenic protective enzyme from broccoli isolation and elucidation of structure. Zhang, Y.;Talalay, P.;Cho, C. G.;Posner, G. H.
  25. Am. J. Clin. Nutr. v.41 no.1 Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Colditz, G. A.;Branch, L. G.;Lipnick, R. J.;Willett, W. C.;Rosner, B.;Posner, B. M.;Hennekens, C. H.
  26. Nutri. Cancer v.12 no.2 The effect of diets enriched in cabbage and collards on murine pulmonary metastasis. Scholar, E. M.;Wolterman, K.;Birt, D. F.;Bresnick, E.
  27. Carcinogenesis v.11 no.7 Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue Bresnick, E.;Birt, D. F.;Wolterman, K.;Wheeker, M.;Markin, R. S.
  28. 한국영양식량학회지 v.21 no.2 녹황색 채소류의 돌연변이유발 억제 및 AZ-521 위암세포의 성장 저해효과. 박건영;이경임;이숙희
  29. Int. J. Cancer v.41 no.3 Diet and cancer of the stomach : a case-control study in china. Hu, J. F.;Zhang, S. F.;Jia, E. M.;Wang, Q. Q.;Liu, S. D.;Liu, Y. Y.;Wu, Y. P.;Cheng, Y. T.
  30. J. Toxicol. Environ. Health. v.25 no.3 Modification of aflatoxin B₁biotransformation in vitro an DNA binding in vivo by dietary broccoli in rats. Ramsdell, H. S.;Eaton, D. L.
  31. J. Natl. Cancer Inst. v.79 no.5 Selenium and cabbage and colon carcinogenesis in mice. Temple, N. J.;Basu, T. K.