Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Subacute Toxicity of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection in Rabbits

  • Shin, Kwang-Soon (College of Veterinary Medicine, Chungnam National University) ;
  • Cho, Sung-Hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Yun, Hyo-In (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Chul-Joong (College of Veterinary Medicine, Chungnam National University) ;
  • Shin, Hyun-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Nam, Sang-Min (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Young-Mi (College of Veterinary Medicine, Chungnam National University) ;
  • Choi, Eun-Ah (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Eun (College of Veterinary Medicine, Chungnam National University) ;
  • Youn, Won-Ki (College of Veterinary Medicine, Chungnam National University) ;
  • Sohn, Hwa-Young (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Dong-Ho (Central Resrarch Institute, Korea Green Cross Corp.,) ;
  • Park, Jong-Il (Toxicology, Research centr, KRICT) ;
  • Cha, Shin-Woo (Toxicology, Research centr, KRICT) ;
  • Ahn, Chang-Nam (Central Resrarch Institute, Korea Green Cross Corp.,) ;
  • Shin, Hyeong-Soon (Dept. of Biotechnology, Inha Univ.)
  • Published : 1997.09.01
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Abstract

The subacute toxicity of the combined vaccine (KGCC-95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection, recently developed by Korea Green Cross Corporation, was investigated. KGCC-95VI was subcutaneously administered into the both sexes of New Zealand White rabbits at the dosage of 0, 10. 50 and 250 ml/kg body weight (20, 100 and 500 times the expected clincal dose) once a day for 30 days. There were no deaths and clinical findings during the experiment period. In both sexes. there were no statistically significant differences between the treated and control groups in urinalysis tests, hematological tests, blood chemistry tests and pathological examinations. The KGCC-95VI is considered not to have the subacute toxicity in the rabbits.

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References

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