Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Primary Skin and Eye Irritation Study of Combined Vaccine (KGCC-95VI) Against Japanese Encephalitis and Hantaan Virus Infection

  • Shin, Kwang-Soon (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Chul-Joong (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
  • Yun, Hyo-In (Veterinary Research Institute, College of Veterinary Medicine, Chungnam National University) ;
  • Park, Jong-Il (Toxicology Research Center, KRICT) ;
  • Cha, Shin-Woo (Toxicology Research Center, KRICT) ;
  • Shin, Hyeong-Soon (Department of Biotechnology, Inha University)
  • Published : 1997.06.01
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Abstract

The primary skin and eye irritancy of the combined vaccine (KGCC-95VI) for the prophylaxis against Japanese encephalitis and Hantaan virus infection recently developed by Korea Green Cross Corporation was investigated. The KGCC-95VI was applied to the back skins of the New Zealand White rabbits. The rabbits were observed for 72 hours and did not exhibit erythema, eschar and edema. The eyes of the rabbits were exposed to the KGCC-95VI. The rabbits were observed for 7 days and did not exhibit any ocular findings on cornea, iris and conjuntivae. The KGCC-95VI is considered not to have the primary skin and eye toxicity in rabbits.

Keywords

References

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