Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Four-Week Intravenous Toxicity Studies of EPO(erythropoietin) in Rabbits

토끼에서 EPO(erythropoietin)의 4주간 정맥 반복투여 독성시험에 관한 연구

  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 양재만 (서울대학교 수의과대학 공중보건학교실) ;
  • 이석만 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이학모 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (실험동물의학교실) ;
  • 송동호 ((주)녹십자) ;
  • 유선희 ((주)녹십자)
  • Published : 1997.06.01
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Abstract

Four-week toxicity of EPO(erythropoietin) was investigated using New Zealand White rabbits according to the established regulations of Korean National Institute of Safety Research. Rabbits were administered intravenously seven days per week for 28 days with dosage of 0, 80, 400 and 2000IU/kg B. W./day. Animals administered with EPO showed no significant changes of body weight, water consumption and feed consumption, and no clinical signs and death. They were not significantly different from the control group in hematological and serum biochemical analysis, urinalysis, prothrombin time, and partial thromboplastin time. In this study, we concluded that EPO had no toxic effect in the New Zealand White rabbits when they were administered intravenously below 2000IU/ kg B.W./ day for 28 days.

Keywords

References

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