Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Toxicity Test with EPO (Erythropoietin) in Rats and Beagle Dogs

랫드와 비글개에서 EPO(Erythropoietin)의 1회 정맥 투여 급성 독성 시험

  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이석만 (서울대학교 수의과대학 공중보건학교실) ;
  • 양재만 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이학모 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (서울대학교 실험동물의학교실) ;
  • 송동호 ((주)녹십자) ;
  • 유선희 ((주)녹십자)
  • Published : 1997.06.01
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Abstract

Acute toxicity of EPO(Erythropoietin) was investigated using rats and beagle dogs according to Established Regulation of Korean National Institute of Safety Research (1994. 4. 14). Rats and beagle dogs were injected intravenously with dosages of 20000 IU/kg, 2000 IU/kg, 200 IU/kg, 20 IU/kg and 2 IU/kg. In animals injected with EPO, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs and autopsy findings. Therefore $LD_50$ of EPO was considered to be higher than 20000 IU/ kg B. W. in rats and beagle dogs.

Keywords

References

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