GROWTH INHIBITION OF Acanthamoeba BY HYDROPEROXYNAPHTALIMIDES UPON PHOTOIRRADIATION

  • Matsugo, Seiichi (Department of Chemical & Biochemical Engineering, Toyarea University) ;
  • Takeuchi, Rie (Department of Chemical & Biochemical Engineering, Toyarea University) ;
  • Takehara, Yoshimi (Dept. of Biology, Faculty of Education, Tokyo Gakugei University) ;
  • Tsuruhara, Takashi (Dept. of Biology, Faculty of Education, Tokyo Gakugei University)
  • Published : 1997.09.01

Abstract

Acanthamoeba strains were photoirradiated in the presence of light-sensitive organic peroxides (hydroperoxynaphthalimide derivatives) including a Photo-Fenton reagent at 366 nm. The survival rates of Acantharnoeba strains determined after 20 h culture showed a significant decrease only upon photoirradiated conditions. The most effective hydroperoxynaphthalimides among these compounds was the bromohydroperoxynaphthalimide (Br-HPO II). The minimum inhibitory concentration (MIC) of Br-HPO II is 100 times lower than that of hydrogen peroxide.

Keywords

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