Skin aging and Antioxidants

피부노화와 항산화제

  • 박수남 (서울산업대학교, 정밀화학과)
  • Published : 1997.03.01

Abstract

피부는 항시 산소와 접촉하고 있고 자오선 조사에 크게 노출되어 있다. 따라서, 활성산소종으로 유도된 피부의 광산화적 손상 위험이 실질적으로 증가하고 있다. 활성산소종이란 한 무리로서 수퍼옥사이드 음이온과 히드록실 라디칼과 같은 산소 중심의 라디칼을 포함할 뿐만 아니라, 과산화수소나 싱글렛 옥시전과 같은 몇 종류의 비라디칼종들, 그 외의 다른 것으로, 활성산소종과 생체 성분과의 반응으로 유래된 과산화 라디칼, 알콕실 라디칼, 히드로과산화물 식세포에서 살균작용을 나타내는 HOCl등을 포함한다. 피부에는 복잡한 항산화 방어망이 발달되어 활성산소종에 대항하여 보호작용을 한다. SOD, 카탈라아제, 글루타치온퍼옥시다제 등의 항산화효소와 $\alpha$-토코페롤, 아스코르브산, 카로티노이드 등의 비효소적 항산화 물질들이 피부 항산화 방어망을 구축하고 있다. 그러나 계속된 자외선에의 노출로 생성된 과잉의 활성산소종은 실질직으로 피부의 효소적 그리고 비효소적 항산화 방어를 위태롭게 한다. 따라서 균형은 산화상태 쪽으로 유리하게 기울어진다 결과적으로 산화적 스트레스는 세포 성분들에 대한 손상을 야기시킨다. 지질 과산화, 단백질 산화, 탄력 섬유인 콜라겐과 엘라스틴의 사슬절단 밀 비장성적인 교차결합, 히아루론산 사슬의 절단, 멜라닌 생성반응 촉진, DNA 산화와 같은 생체 구성 성분들의 손상이 일어난다. 결국에는 탄력감소, 주름살 및 기미, 주근깨 등으로 특징 지워지는 피부노화가 가속화된다. 따라서 필요한 항상화제를 함유한 식품이나 화장품을 통한 계속적인 항산화제 보충으로 피부 항산화 방어망을 견고히 할 때 피부노화는 지연되고 억제될 것이다.주거를 구분하고 있는 것으로 조사되었으나, 아직까지 절반 가량(52.2%)의 상점들이 다른 사람 소유의 건물을 전 ·월세로 임대하여 사용하고 있음을 알 수 있었다. 이상에서 살펴본 바와 같이 고수동굴 주변의 상업적 특성은 90년대에 들어서면서 자기 고장에 있는 관광자원을 내 고향의 자랑거리로 생각하고 이를 지역발전의 밑거름으로 활용하고자 하는 인식이 늘어나고 있음을 알 수 있었다. 그러나, 관광지로서의 특성이라 할 수 있는 다른 관광동굴과의 차별성이 부족하다고 할 수 있다. 즉 다른 지역의 기념품점에서 구입할 수 없는 고수동굴만이 갖고 있는 특징적인 기념품을 판매함으로써 관광객의 구매욕구를 높인다거나 고수동굴의 일주관광 후 관광객을 좀 더 머무르게 할 수 있는 시설의 개발이 더 필요하다.유의한 차이를 나타내는 항목이 많았으며 12주에서 vehicle과 유의적인 차이를 나타내는 항목도 많으므로 3-APPA가 APSA 보다 광범위한 피부노화 억제 효과를 갖는 물질이라고 할 수 있다.주도적 역할을 수행해야 할 것이다. 넷째, 선박금융제도의 개선과 신금융상품의 개발이 요구된다. 내수 수요인 계획조선의 지원조건을 개선하고 연불수출자금을 BBC자금으로 활용토록하여 국내 선주들의 신조를 유도해야 할 것이다. 그 외에 향후 금융개방화에 맞추어 해외자금을 활용한 리스금융, 상사금융 등의 민간신용제도를 더욱 활성화하고 선진국의 선박금융기법에 대한 연구 및 도입 등 선주들에게 다양한 선박건조자금을 제공하여 내수기반 확충에도 노력해야 할 것 이다.있었다., 인삼이 성장될 때 부분적인 영양상태의 불충분이나 기후 등에 따른 영향을 받을 수 있기 때문에 앞으로 이에 대한 많은 연구가

Keywords

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