Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지

Development of lontophoresis System for Transdermal Drug Delivery

약물치료법의 개선을 위한 이온토포레시스 시스템의 개발

  • 양경모 (원광대학교 전자공학과, 원광보건전문대학교 물리치료과)
  • Published : 1997.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Recently there has been increased interest in the use of iontophoresis for the transdermal delivery of drugs, both ionic and nonionic. The use of iontophoresis has been rare over the years due to the lack of domestic supplies of the instrument and the expensive iontophoresis instrument made by foreign country. The purpose of this study was to design a commercially available iontophoresis system (WIT- 1 ). The efficacy of WT- 1 system was well defined. In clinical trial, procaine iontophoresis produced local anesthesia of significantly longer duration than swabbing and placebo groups. The 4% procaine iontophoresis using WIT-1 significant difference in anesthetic duration between WIT- 1 system and IontopherTM PM system. The result of this study suggest that WIT-1 system can be used for the transdermal delivery of drugs in various clinical conditions.

Keywords

References

  1. A Manual of Electrotherapy. (2nd ed.) A.L.Watkins
  2. Therapeutic Electricity and Ultrabiolet Radiation (2nd ed.) R. Harris;Iontophoresis;Licht s(Ed.)
  3. Theraperutic Electricity and Ultraviolet Radiation (3rd ed.) History of Electrotherapy S. Licht;Stiwell GK(ed.)
  4. Am. J. Hosp. Pharm v.37 Lidocaine anesthesia: comparisonof iontophoresis, injection, and swabbing J. Russo;A.G. Lipman;T.J. Comstocck;B.C. Page;R.L. Stephen
  5. Phys Ther v.75 Iontophoresis: Applications in transdermal medication delivery C.T. Costello;A.H. Jeske
  6. J. Sci. Pharm v.67 Conductivility of drugs used for ionthphoresis L.P. Sr Gangarosa;N.H. Park;B.C. Fong;Scott DF;Hill JM
  7. Phys. Ther v.51 Use of low voltage electrotherapy and electromyography in physical therapy L. Amrein;T.R. Garrett;G.M. Martin
  8. J Pharm Sci. v.78 Inotophoretic(transdermal) delivery of drugs: Overview of historical development Y.W. Chien;A.K. Bange
  9. 대한물리치료학회지 v.7 음이온도입이 세균성장에 미치는 영향 이재형;김주영;제갈승주
  10. J. Laryngol Otol v.104 Anaesthesia of the thympanic membrane: comparison of EMLA cream an inotophoresis K.S. Sirimanna;G.J. MaddenS;.Miles
  11. Am J Physiol v.257 Selective abolition of adrenergic vasoconstrictor responeses in skin by local iontophoresis of bretylium D.L. Jr Kellogg;J.M. Johnson;W.A. Kosiba
  12. Phys. Ther v.58 Antibiotic iontophoresis in the treatment of ear chondritis N.T. LaForrest;C. Confrancesco
  13. Physiological basis of rehabilitation (2nd ed.) Physiology of the Skin J.H. Prystowsky;L.C. Harber;J.A. Downey(et al.)
  14. Bioelectrochem and Bioenergye v.3 Some specific cellular effects of electrically injected silver and gold ions J.A. Spadaro;R.O. Becker
  15. Antimicrob Agents Chemother v.6 Antibacterial effects of silver electrodes with weak direct current J.A. Spadaro;R.O. Becker;T.J. Berger;S.E. Chapin;S.E. Barranco
  16. J Pharm Sci. v.78 Iontophoretic delivery of nonpeptide drugs: fromulation optimization for maximum skin permeability J.E. Sanderson;S.Dereil;R. DIxon