Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Food on the Pharmacokinetics of YH439 and Its Metabolites in Rats

  • Published : 1997.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The pharmacokinetics of YH439 and its metabolites were investigated after oral administration of YH439 to rats to investigate the food effect. After oral administration of YH439, its metabolites, M4 and M5 were detected in plasma. YH439 was not detected in the plasma for both fasted and fed rats for all doses studied. The pharmacokinetic parameters of the metabolites were not affected by food at all doses studied. The results of this study indicated that there are no significant food effects on the pharmacokinetics of YH439 and its metabolites in rats.

Keywords

References

  1. Gut v.16 The effect of tea on iron absorption Disler,P.B.;Lynch,S.R.;Charlton,R.W.;Torrance,J.D.;Bothwell,T.H.;Walker,R.B.;Mayet,F.
  2. Clin. Pharmacol. Ther. v.24 Diazepam absorption: effects of food and antacids Greenblatt,D.J.;Allen,M.D.;McLaughlin,D.S.;Harmatz,J.S.;Shader,R.I.
  3. Biopharm. Drug Dispos. v.16 Factors influencing the protein binding of YH439 using an equilibrium dialysis technique. A new hepatoprotective agent Lee,W.I.;Yoon,Y.H.;Park,J.H.;Lee,J.W.;Shim,C.K.;Lee,M.G.
  4. Eur. J. Clin. Pharmacol. v.38 Mechanism and variations in the food effect on propranolol bioavailability Leidholm,H.;Wahlin-Boll,E.;Melander,A.
  5. Clin. Pharmacol. Ther. v.22 Enhancement of the bioavailability of propranolol and metoprolol by food Melander,A.;Danielson,K.;Schersten,B.;Wahlin,E.
  6. Eur. J. Clin. Pharmacol. v.31 Influence of bile salts and liqids on intestinal absorption of griseofulvin in man Palma,R.;Vidon,N.;Houin,G.;Pfeiffer,A.;Rongier,M.;Barre,J.;Bernier,J.
  7. The International Symposium on the Role of Drug Metabolism and Pharmacokinetic Research in New Drug Development;Proceedings Metabolism of a new hepatoprotective agent, YH439 Park,J.S.
  8. J. Rheumatol. v.10 Influence of food on the bioavailablity of penicillamine Schuna,A.;Osman,M.A.;Patel,R.B.;Welling,P.G.;Sundstrom,W.P.
  9. N. Y. State. J. Med. v.78 Tetracyclines: New look at old antibiotic Siegel,D.
  10. Klin. Wochenschr. v.65 The influence of food on the systemic availability of drugs. Part 1. Drug absorption Walter-Sack,I.
  11. J. Chromatogr. B. Simultaneous determination of a new hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7 in plasma and urine by high performance liquid chromatography Yoon,W.H.;Yoo,J.K.;Lee,J.W.;Shim,C.K.;Lee,M.G.
  12. Drug Metab. Dispos. Species differences in pharmacokinetics of a hepatoprotective agent, YH439, and its metabolites M4, M5, and M7, after intravenous and oral administration to rats, rabbits, and dogs Yoon,W.H.;Yoo,J.K.;Lee,J.W.;Shim,C.K.;Lee,M.G.
  13. Drug Stab. v.1 Stability and blood partition of YH439. A new-hepatoprotective agent Yoon,W.H.;Park,J.H.;Lee,W.I.;Lee,J.W.;Shim,C.K.;Lee,M.G.