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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of novel Heterocycles Through Reaction of Indolin-2-one Derivatives with Active Methylene and Amino Reagents

  • Abdel-Latif, F.F. (Chemistry Department Faculty of Science, El-Minia University) ;
  • Ahmed, E.Kh. (Chemistry Department Faculty of Science, El-Minia University) ;
  • Mekheimer, R. (Chemistry Department Faculty of Science, El-Minia University) ;
  • Mashaly, M.M. (Chemstry Department Mansoura University)
  • Published : 1997.10.01
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Abstract

Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.

Keywords

References

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