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The Pharmaceutical Society of Korea (대한약학회)
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Antioxidant Effect of Salvia miltiorrhiza

  • Kang, Hye-Sook (Department of Food and Life Science, Pukyoung National University) ;
  • Chung, Hae-Young (Department of Pharmacy, Pusan National University) ;
  • Jung, Jee-Hyung (Department of Pharmacy, Pusan National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Choi, Jae-Sue (Department of Food and Life Science, Pukyoung National University)
  • Published : 1997.10.01
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Abstract

A strong antioxidant activity, which was measured by the radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl(DPPH) radical, was detected in the methanol extract of Salvia miltiorrhiza Bunge (Labiatae). By activity-directed fractionation, compounds 1 and 2 were isolated as antioxidant principles of S. miltiorrhiza. Compounds 1 and 2 were identified as dimethyl lithospermate and 3-(3, 4-dihydroxyphenyl)lactamide, respectively, on the basis of spectral data. The radical scavenging effect of compounds 1 and 2 on DPPH radical exceeded that of L-ascorbic acid which is a well known antioxidant. These two compounds also showed prominent inhibitory activity against free radical generation in dichlorofluorescein (DCF) method and cytoprotective effect against t-BHP in cultured liver cell.

Keywords

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